Nicotine blood levels and short-term smoking reduction with an electronic nicotine delivery system

Mitchell A. Nides, Scott J. Leischow, Meghna Bhatter, Michael Simmons

Research output: Contribution to journalArticle

68 Scopus citations


Objectives: To evaluate nicotine delivery from the NJOY® King Bold Electronic Nicotine Delivery System (ENDS) and its short-term potential for smoking reduction or cessation. Methods: One week of ad libitum use was followed by measurements of plasma nicotine, heart rate, and craving and withdrawal after 12 hours of nicotine abstinence in 25 adult smokers not interested in quitting. Results: After 5 minutes of use, blood nicotine levels increased by a mean of 3.5 ng/mL (p < .001), heart rate increased, and craving was reduced by 55%. Cigarettes per day were reduced by 39% during the test week, and perceptions of use for reduction or cessation were positive. Conclusions: The NJOY® King Bold ENDS delivers nicotine and led to short-term smoking reduction. Copyright (c) PNG Publications. All rights reserved.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalAmerican Journal of Health Behavior
Issue number2
StatePublished - Mar 1 2014



  • Electronic cigarette
  • Nicotine delivery
  • Smoking cessation

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health

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