Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats

Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Joo Ho Chung, Hyung Sook Kang, Soon Ah Kang, Ryo Won Choue, Ee Hwa Kim, Chang Ju Kim

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26 Scopus citations

Abstract

Effect of nicotine on nitric oxide synthase (NOS) expression in various hypothalamic regions was investigated in rats via nicotineamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Sprague-Dawley rats were divided into the fed group, the fed and nicotine-treated group, the food-deprived group, and the food-deprived and nicotine-treated group. The fed groups received abundant food and water, while food was withheld from the food-deprived groups for 48 h. The nicotine-treated groups were injected with nicotine. Following food deprivation, enhanced NAPDH-d expression was detected in the paraventricular nucleus, ventromedial hypothalamic nucleus, and lateral hypothalamic area of the hypothalamus. Nicotine administration to the food-deprived rats resulted in decreased NADPH-d positivity. The present results indicate that nicotine administration is effective in limiting the enhancement in NOS expression following food restriction.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Volume322
Issue number1
DOIs
StatePublished - Mar 29 2002

Keywords

  • Hypothalamus
  • Lateral hypothalamic area
  • Nicotine
  • Nicotineamide adenine dinucleotide phosphate-diaphorase histochemistry
  • Paraventricular nucleus
  • Ventromedial hypothalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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    Jang, M. H., Shin, M. C., Lim, B. V., Chung, J. H., Kang, H. S., Kang, S. A., Choue, R. W., Kim, E. H., & Kim, C. J. (2002). Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats. Neuroscience Letters, 322(1), 29-32. https://doi.org/10.1016/S0304-3940(02)00076-9