Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats

Mi-Hyeon D Jang, Min Chul Shin, Baek Vin Lim, Joo Ho Chung, Hyung Sook Kang, Soon Ah Kang, Ryo Won Choue, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Effect of nicotine on nitric oxide synthase (NOS) expression in various hypothalamic regions was investigated in rats via nicotineamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Sprague-Dawley rats were divided into the fed group, the fed and nicotine-treated group, the food-deprived group, and the food-deprived and nicotine-treated group. The fed groups received abundant food and water, while food was withheld from the food-deprived groups for 48 h. The nicotine-treated groups were injected with nicotine. Following food deprivation, enhanced NAPDH-d expression was detected in the paraventricular nucleus, ventromedial hypothalamic nucleus, and lateral hypothalamic area of the hypothalamus. Nicotine administration to the food-deprived rats resulted in decreased NADPH-d positivity. The present results indicate that nicotine administration is effective in limiting the enhancement in NOS expression following food restriction.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Volume322
Issue number1
DOIs
StatePublished - Mar 29 2002
Externally publishedYes

Fingerprint

Nicotine
Nitric Oxide Synthase
Hypothalamus
Food
Adenine
Phosphates
Ventromedial Hypothalamic Nucleus
Lateral Hypothalamic Area
Food Deprivation
Paraventricular Hypothalamic Nucleus
Sprague Dawley Rats
Water

Keywords

  • Hypothalamus
  • Lateral hypothalamic area
  • Nicotine
  • Nicotineamide adenine dinucleotide phosphate-diaphorase histochemistry
  • Paraventricular nucleus
  • Ventromedial hypothalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats. / Jang, Mi-Hyeon D; Shin, Min Chul; Lim, Baek Vin; Chung, Joo Ho; Kang, Hyung Sook; Kang, Soon Ah; Choue, Ryo Won; Kim, Ee Hwa; Kim, Chang Ju.

In: Neuroscience Letters, Vol. 322, No. 1, 29.03.2002, p. 29-32.

Research output: Contribution to journalArticle

Jang, Mi-Hyeon D ; Shin, Min Chul ; Lim, Baek Vin ; Chung, Joo Ho ; Kang, Hyung Sook ; Kang, Soon Ah ; Choue, Ryo Won ; Kim, Ee Hwa ; Kim, Chang Ju. / Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats. In: Neuroscience Letters. 2002 ; Vol. 322, No. 1. pp. 29-32.
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