Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats

Mi-Hyeon D Jang, Min Chul Shin, Khae Hawn Kim, Seong Yeon Cho, Geon Ho Bahn, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effects of nicotine on the expressions of neuropeptide Y (NPY) and leptin receptor in the rat hypothalamus were investigated via immunohistochemistry. The results show that NPY expression is not affected in the arcuate nucleus (ARN) and is increased only slightly in the paraventricular nucleus (PVN) by nicotine administration under normal (i.e. fed) conditions and that leptin receptor expression is decreased slightly in the ARN and not affected in the PVN following nicotine treatment under the same conditions. Food deprivation enhanced NPY and suppressed leptin receptor expression in the ARN and PVN of the hypothalamus. Nicotine administration resulted in decreased NPY and increased leptin receptor levels.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalBrain Research
Volume964
Issue number2
DOIs
StatePublished - Feb 28 2003
Externally publishedYes

Fingerprint

Leptin Receptors
Neuropeptide Y
Nicotine
Arcuate Nucleus of Hypothalamus
Hypothalamus
Paraventricular Hypothalamic Nucleus
Food
Neuropeptide Y Receptors
Food Deprivation
Immunohistochemistry
Therapeutics

Keywords

  • Hypothalamus
  • Immunohistochemistry
  • Leptin receptor
  • Neuropeptide Y
  • Nicotine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. / Jang, Mi-Hyeon D; Shin, Min Chul; Kim, Khae Hawn; Cho, Seong Yeon; Bahn, Geon Ho; Kim, Ee Hwa; Kim, Chang Ju.

In: Brain Research, Vol. 964, No. 2, 28.02.2003, p. 311-315.

Research output: Contribution to journalArticle

Jang, Mi-Hyeon D ; Shin, Min Chul ; Kim, Khae Hawn ; Cho, Seong Yeon ; Bahn, Geon Ho ; Kim, Ee Hwa ; Kim, Chang Ju. / Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats. In: Brain Research. 2003 ; Vol. 964, No. 2. pp. 311-315.
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