Abstract
Nickel (Ni) wire implants into the CNS of Lewis rats induce the formation of structures morphologically similar to Rosenthal fibers (RF) seen in human conditions. We describe in detail the time courses of Ni-induced changes in rat astrocytes and compare the Ni-induced RF with RF occurring in focal lesions. Immunocyto-chemistry at the level of electron microscopy suggests that the Ni-induced RF are largely made up of plasma proteins. We suggest that the mechanism of RF formation and possibly the protein composition of RF depends on the condition in which they are found.
Original language | English (US) |
---|---|
Pages (from-to) | 664-675 |
Number of pages | 12 |
Journal | Journal of Neuropathology and Experimental Neurology |
Volume | 41 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1982 |
Keywords
- Alexander’s disease
- Astrocytes
- Glial fibrillary acidic protein
- Glial filaments
- Nickel
- Plasma proteins
- Rosenthal fibers
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience