Niacin-Induced Hepatitis: A Potential Side Effect With Low-Dose Time-Release Niacin

JEFF A. ETCHASON; TODD D. MILLER; RAY W. SQUIRES; THOMAS G. ALLISON; GERALD T. GAU; JAMES K. MARTTILA; BRUCE A. KOTTKE

doi:10.1016/S0025-6196(12)61171-9

Niacin-Induced Hepatitis: A Potential Side Effect With Low-Dose Time-Release Niacin

JEFF A. ETCHASON, TODD D. MILLER, RAY W. SQUIRES, THOMAS G. ALLISON, GERALD T. GAU, JAMES K. MARTTILA, BRUCE A. KOTTKE

Cardiovascular Medicine

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Abstract

Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks). This manifestation of hepatotoxicity seems to differ from that previously reported in association with use of crystalline niacin, which occurred with high dosage and prolonged usage of the medication. In view of the recent increased frequency of prescribing niacin for the treatment of hyperlipidemia, physicians should be aware of the potential for hepatotoxicity with even low-dose and short-term use of time-release niacin.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Mayo Clinic proceedings
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/S0025-6196(12)61171-9
State	Published - Jan 1 1991

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Medicine(all)

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title = "Niacin-Induced Hepatitis: A Potential Side Effect With Low-Dose Time-Release Niacin",

abstract = "Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks). This manifestation of hepatotoxicity seems to differ from that previously reported in association with use of crystalline niacin, which occurred with high dosage and prolonged usage of the medication. In view of the recent increased frequency of prescribing niacin for the treatment of hyperlipidemia, physicians should be aware of the potential for hepatotoxicity with even low-dose and short-term use of time-release niacin.",

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T2 - A Potential Side Effect With Low-Dose Time-Release Niacin

AU - ETCHASON, JEFF A.

AU - MILLER, TODD D.

AU - SQUIRES, RAY W.

AU - ALLISON, THOMAS G.

AU - GAU, GERALD T.

AU - MARTTILA, JAMES K.

AU - KOTTKE, BRUCE A.

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AB - Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks). This manifestation of hepatotoxicity seems to differ from that previously reported in association with use of crystalline niacin, which occurred with high dosage and prolonged usage of the medication. In view of the recent increased frequency of prescribing niacin for the treatment of hyperlipidemia, physicians should be aware of the potential for hepatotoxicity with even low-dose and short-term use of time-release niacin.

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Niacin-Induced Hepatitis: A Potential Side Effect With Low-Dose Time-Release Niacin

Abstract

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