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Translated title of the contribution: New strategies for tendon healing

H. D. Möller, C. H. Evans, N. Maffulli

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

This review describes structure, function and healing of tendinous tissue and discusses new biologically based treatment options to modulate tendon healing. The repair process after tendon rupture results in a morphologically different and biomechanically inferior structure compared to a normal tendon. The collagen fibril diameters are decreased months after the traumatic lesion and show also different phenotypes. We know that cytokines and growth factors are key components for normal tissue development and regulate wound healing processes. Some growth factors have been detected to influence tenocytes by promoting cell proliferation and matrix synthesis. Application of the adequate growth factors at certain periods during the repair process might improve the healing result after tendon rupture. However, most of these growth factors are proteins which are rapidly metabolized by the organism. Transfer of growth factor genes into tenocytes might eliminate this problem by a continuous local release of growth factors at the healing site.

Translated title of the contributionNew strategies for tendon healing
Original languageGerman
Pages (from-to)182-187
Number of pages6
JournalOrthopade
Volume29
Issue number3
DOIs
StatePublished - Mar 2000

Keywords

  • Collagen
  • Gene therapy
  • Growth factors
  • Tendon healing

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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