New staging system and a registry for perihilar cholangiocarcinoma

Michelle L. Deoliveira, Richard D. Schulick, Yuji Nimura, Charles Rosen, Gregory James Gores, Peter Neuhaus, Pierre Alain Clavien

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Perihilar cholangiocarcinoma is one of the most challenging diseases with poor overall survival. The major problem for anyone trying to convincingly compare studies among centers or over time is the lack of a reliable staging system. The most commonly used system is the Bismuth-Corlette classification of bile duct involvement, which, however, does not include crucial information such as vascular encasement and distant metastases. Other systems are rarely used because they do not provide several key pieces of information guiding therapy. Therefore, we have designed a new system reporting the size of the tumor, the extent of the disease in the biliary system, the involvement of the hepatic artery and portal vein, the involvement of lymph nodes, distant metastases, and the volume of the putative remnant liver after resection. The aim of this system is the standardization of the reporting of perihilar cholangiocarcinoma so that relevant information regarding resectability, indications for liver transplantation, and prognosis can be provided. With this tool, we have created a new registry enabling every center to prospectively enter data on their patients with hilar cholangiocarcinoma. The availability of such standardized and multicenter data will enable us to identify the critical criteria guiding therapy.

Original languageEnglish (US)
Pages (from-to)1363-1371
Number of pages9
JournalHepatology
Volume53
Issue number4
DOIs
StatePublished - Apr 2011

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Klatskin Tumor
Registries
Neoplasm Metastasis
Bismuth
Hepatic Veins
Hepatic Artery
Biliary Tract
Portal Vein
Bile Ducts
Liver Transplantation
Blood Vessels
Lymph Nodes
Survival
Liver
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Hepatology

Cite this

Deoliveira, M. L., Schulick, R. D., Nimura, Y., Rosen, C., Gores, G. J., Neuhaus, P., & Clavien, P. A. (2011). New staging system and a registry for perihilar cholangiocarcinoma. Hepatology, 53(4), 1363-1371. https://doi.org/10.1002/hep.24227

New staging system and a registry for perihilar cholangiocarcinoma. / Deoliveira, Michelle L.; Schulick, Richard D.; Nimura, Yuji; Rosen, Charles; Gores, Gregory James; Neuhaus, Peter; Clavien, Pierre Alain.

In: Hepatology, Vol. 53, No. 4, 04.2011, p. 1363-1371.

Research output: Contribution to journalArticle

Deoliveira, ML, Schulick, RD, Nimura, Y, Rosen, C, Gores, GJ, Neuhaus, P & Clavien, PA 2011, 'New staging system and a registry for perihilar cholangiocarcinoma', Hepatology, vol. 53, no. 4, pp. 1363-1371. https://doi.org/10.1002/hep.24227
Deoliveira ML, Schulick RD, Nimura Y, Rosen C, Gores GJ, Neuhaus P et al. New staging system and a registry for perihilar cholangiocarcinoma. Hepatology. 2011 Apr;53(4):1363-1371. https://doi.org/10.1002/hep.24227
Deoliveira, Michelle L. ; Schulick, Richard D. ; Nimura, Yuji ; Rosen, Charles ; Gores, Gregory James ; Neuhaus, Peter ; Clavien, Pierre Alain. / New staging system and a registry for perihilar cholangiocarcinoma. In: Hepatology. 2011 ; Vol. 53, No. 4. pp. 1363-1371.
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