New monoclonal antibodies for the treatment of acute lymphoblastic leukemia

Nosha Farhadfar, Mark R Litzow

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Monoclonal antibodies represent a major advance in treatment of acute lymphoblastic leukemia (ALL). Targeted delivery of these agents based on leukemic cell-surface receptor recognition, improves efficacy and minimizes off-target toxicity. The antigens CD19, CD20, CD22 and CD52, are the most common antigens to which monoclonal antibodies in B-cell ALL have been directed. Rituximab, an anti-CD20 antibody, in combination with conventional chemotherapy has been shown to improve survival in newly diagnosed CD20 positive B-cell ALL. Blinatumomab, a bispecific T-cell engager, as monotherapy in relapsed and refractory B-cell ALL resulted in prolonged relapse free survival. Inotuzumab ozogamicin, an anti-CD22 antibody, alone and in combination with chemotherapy has been promising in relapsed and refractory B-cell ALL. The effectiveness and safety of several newer monoclonal antibodies including ofatumumab, obinutuzumab, epratuzumab, denintuzumab mafodotin and moxetumomab pasudotox as single agents or in combination with a chemotherapeutic back bone are currently under investigation.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalLeukemia Research
Volume49
DOIs
StatePublished - Oct 1 2016

Keywords

  • Acute lymphoblastic leukemia (ALL)
  • Monoclonal antibodies
  • Targeted therapy

ASJC Scopus subject areas

  • Medicine(all)
  • Hematology
  • Oncology
  • Cancer Research

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