New modalities for understanding dynamic regulation of the somatotropic (GH) axis: Explication of gender differences in GH neuroregulation in the human

Johannes D Veldhuis

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Neuroendocrine regulation of the somatotropic (GR) axis is under the direction of hypothalamic signals, intrapituitary mechanisms, and multi-level feedback control. Consequently, understanding the regulation of the physiologically pulsatile mode of GH release in vivo is a substantial challenge. Objectives: To present and review several new modalities designed to unmask novel features of physiological regulation of the GH axis. To this end, I emphasize gender differences in the control of pulsatile GH release, while highlighting the new approaches to uncovering such differences. Subjects: Human volunteers. Methods: Novel investigative modalities include: (1) a high-sensitivity chemiluminescence GH assay capable of measuring 0.002 μg/l of GH when utilized with a new discrete variance model for assay data reduction; (2) the technique of standardized linear regression to compare GB measures in men versus women; (3) the application of so-called deconvolution analysis, which is designed to estimate underlying rates of pulsatile hormone (GB) secretion as well as hormone half-life from a given plasma GH concentration profile; (4) an approximate entropy (ApEn) statistic to quantify the regularity or orderliness of hormone release, by assigning a single non-negative number that is a measure of the pattern reproducibility in the data; and (5) the evolution of network models to represent the physiological connections and feedback activities of the GH axis. Results: The foregoing new methodologies have collectively uncovered prominent gender differ ences in the regulation of the GH axis, which encompass: (i) higher mean serum GH concentrations due to greater GH secretory burst mass in women than men; (ii) relatively reduced suppressibility of GH by oral glucose administration due to greater GH secretory burst mass in women compared to men, with no apparent gender differences in the frequency of GH secretory bursts or the GH half-life in plasma; (iv) a remarkably higher degree of irregularity or disorder in the GH release process in women or female rats compared to male counterparts, indicating significantly reduced pattern reproducibility in the female; (v) an approximately two-fold greater sensitivity of men compared to women to the negative effects of age and increased percentage body fat and the positive impact of physical fitness on mean serum GB[ concentrations; and (vi) the ability of a multinodal network to capture the feedback relationships observed in vivo among GHRH somatostatin, GH secretion, and GH and IGF-I negative feedback. Conclusions: New analytical modalities for understanding dynamic regulation of the GH axis disclose a wide array of specific, prominent, and quantifiable gender differences in the physiological control mechanisms that direct this important neuroendocrine axis.

Original languageEnglish (US)
Pages (from-to)237-253
Number of pages17
JournalJournal of Pediatric Endocrinology and Metabolism
Volume9
Issue numberSUPPL.
StatePublished - 1996
Externally publishedYes

Fingerprint

Hormones
Half-Life
Physiological Feedback
Physical Fitness
Entropy
Luminescence
Somatostatin
Serum
Insulin-Like Growth Factor I
Oral Administration
Adipose Tissue
Volunteers
Linear Models
Glucose
Direction compound

Keywords

  • Female
  • Gender
  • GH
  • Human
  • Male
  • Pulsatile
  • Secretion

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{5811677e22124c76a601d45ab7382f80,
title = "New modalities for understanding dynamic regulation of the somatotropic (GH) axis: Explication of gender differences in GH neuroregulation in the human",
abstract = "Background: Neuroendocrine regulation of the somatotropic (GR) axis is under the direction of hypothalamic signals, intrapituitary mechanisms, and multi-level feedback control. Consequently, understanding the regulation of the physiologically pulsatile mode of GH release in vivo is a substantial challenge. Objectives: To present and review several new modalities designed to unmask novel features of physiological regulation of the GH axis. To this end, I emphasize gender differences in the control of pulsatile GH release, while highlighting the new approaches to uncovering such differences. Subjects: Human volunteers. Methods: Novel investigative modalities include: (1) a high-sensitivity chemiluminescence GH assay capable of measuring 0.002 μg/l of GH when utilized with a new discrete variance model for assay data reduction; (2) the technique of standardized linear regression to compare GB measures in men versus women; (3) the application of so-called deconvolution analysis, which is designed to estimate underlying rates of pulsatile hormone (GB) secretion as well as hormone half-life from a given plasma GH concentration profile; (4) an approximate entropy (ApEn) statistic to quantify the regularity or orderliness of hormone release, by assigning a single non-negative number that is a measure of the pattern reproducibility in the data; and (5) the evolution of network models to represent the physiological connections and feedback activities of the GH axis. Results: The foregoing new methodologies have collectively uncovered prominent gender differ ences in the regulation of the GH axis, which encompass: (i) higher mean serum GH concentrations due to greater GH secretory burst mass in women than men; (ii) relatively reduced suppressibility of GH by oral glucose administration due to greater GH secretory burst mass in women compared to men, with no apparent gender differences in the frequency of GH secretory bursts or the GH half-life in plasma; (iv) a remarkably higher degree of irregularity or disorder in the GH release process in women or female rats compared to male counterparts, indicating significantly reduced pattern reproducibility in the female; (v) an approximately two-fold greater sensitivity of men compared to women to the negative effects of age and increased percentage body fat and the positive impact of physical fitness on mean serum GB[ concentrations; and (vi) the ability of a multinodal network to capture the feedback relationships observed in vivo among GHRH somatostatin, GH secretion, and GH and IGF-I negative feedback. Conclusions: New analytical modalities for understanding dynamic regulation of the GH axis disclose a wide array of specific, prominent, and quantifiable gender differences in the physiological control mechanisms that direct this important neuroendocrine axis.",
keywords = "Female, Gender, GH, Human, Male, Pulsatile, Secretion",
author = "Veldhuis, {Johannes D}",
year = "1996",
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journal = "Journal of Pediatric Endocrinology and Metabolism",
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T1 - New modalities for understanding dynamic regulation of the somatotropic (GH) axis

T2 - Explication of gender differences in GH neuroregulation in the human

AU - Veldhuis, Johannes D

PY - 1996

Y1 - 1996

N2 - Background: Neuroendocrine regulation of the somatotropic (GR) axis is under the direction of hypothalamic signals, intrapituitary mechanisms, and multi-level feedback control. Consequently, understanding the regulation of the physiologically pulsatile mode of GH release in vivo is a substantial challenge. Objectives: To present and review several new modalities designed to unmask novel features of physiological regulation of the GH axis. To this end, I emphasize gender differences in the control of pulsatile GH release, while highlighting the new approaches to uncovering such differences. Subjects: Human volunteers. Methods: Novel investigative modalities include: (1) a high-sensitivity chemiluminescence GH assay capable of measuring 0.002 μg/l of GH when utilized with a new discrete variance model for assay data reduction; (2) the technique of standardized linear regression to compare GB measures in men versus women; (3) the application of so-called deconvolution analysis, which is designed to estimate underlying rates of pulsatile hormone (GB) secretion as well as hormone half-life from a given plasma GH concentration profile; (4) an approximate entropy (ApEn) statistic to quantify the regularity or orderliness of hormone release, by assigning a single non-negative number that is a measure of the pattern reproducibility in the data; and (5) the evolution of network models to represent the physiological connections and feedback activities of the GH axis. Results: The foregoing new methodologies have collectively uncovered prominent gender differ ences in the regulation of the GH axis, which encompass: (i) higher mean serum GH concentrations due to greater GH secretory burst mass in women than men; (ii) relatively reduced suppressibility of GH by oral glucose administration due to greater GH secretory burst mass in women compared to men, with no apparent gender differences in the frequency of GH secretory bursts or the GH half-life in plasma; (iv) a remarkably higher degree of irregularity or disorder in the GH release process in women or female rats compared to male counterparts, indicating significantly reduced pattern reproducibility in the female; (v) an approximately two-fold greater sensitivity of men compared to women to the negative effects of age and increased percentage body fat and the positive impact of physical fitness on mean serum GB[ concentrations; and (vi) the ability of a multinodal network to capture the feedback relationships observed in vivo among GHRH somatostatin, GH secretion, and GH and IGF-I negative feedback. Conclusions: New analytical modalities for understanding dynamic regulation of the GH axis disclose a wide array of specific, prominent, and quantifiable gender differences in the physiological control mechanisms that direct this important neuroendocrine axis.

AB - Background: Neuroendocrine regulation of the somatotropic (GR) axis is under the direction of hypothalamic signals, intrapituitary mechanisms, and multi-level feedback control. Consequently, understanding the regulation of the physiologically pulsatile mode of GH release in vivo is a substantial challenge. Objectives: To present and review several new modalities designed to unmask novel features of physiological regulation of the GH axis. To this end, I emphasize gender differences in the control of pulsatile GH release, while highlighting the new approaches to uncovering such differences. Subjects: Human volunteers. Methods: Novel investigative modalities include: (1) a high-sensitivity chemiluminescence GH assay capable of measuring 0.002 μg/l of GH when utilized with a new discrete variance model for assay data reduction; (2) the technique of standardized linear regression to compare GB measures in men versus women; (3) the application of so-called deconvolution analysis, which is designed to estimate underlying rates of pulsatile hormone (GB) secretion as well as hormone half-life from a given plasma GH concentration profile; (4) an approximate entropy (ApEn) statistic to quantify the regularity or orderliness of hormone release, by assigning a single non-negative number that is a measure of the pattern reproducibility in the data; and (5) the evolution of network models to represent the physiological connections and feedback activities of the GH axis. Results: The foregoing new methodologies have collectively uncovered prominent gender differ ences in the regulation of the GH axis, which encompass: (i) higher mean serum GH concentrations due to greater GH secretory burst mass in women than men; (ii) relatively reduced suppressibility of GH by oral glucose administration due to greater GH secretory burst mass in women compared to men, with no apparent gender differences in the frequency of GH secretory bursts or the GH half-life in plasma; (iv) a remarkably higher degree of irregularity or disorder in the GH release process in women or female rats compared to male counterparts, indicating significantly reduced pattern reproducibility in the female; (v) an approximately two-fold greater sensitivity of men compared to women to the negative effects of age and increased percentage body fat and the positive impact of physical fitness on mean serum GB[ concentrations; and (vi) the ability of a multinodal network to capture the feedback relationships observed in vivo among GHRH somatostatin, GH secretion, and GH and IGF-I negative feedback. Conclusions: New analytical modalities for understanding dynamic regulation of the GH axis disclose a wide array of specific, prominent, and quantifiable gender differences in the physiological control mechanisms that direct this important neuroendocrine axis.

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