New Insights into Vinculin Function and Regulation

Xiao Peng, Elke S. Nelson, Jessica Maiers, Kris A. DeMali

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens junctions that is essential for embryonic development. Much is now known regarding the role of vinculin in governing cell-matrix adhesion. In the past decade that the crystal structure of vinculin and the molecular details for how vinculin regulates adhesion events have emerged. The recent data suggests a critical function for vinculin in regulating integrin clustering, force generation, and strength of adhesion. In addition to an important role in cell-matrix adhesion, vinculin is also emerging as a regulator of apoptosis, Shigella entry into host cells, and cadherin-based cell-cell adhesion. A close inspection of this work reveals that there are similarities between vinculin's role in focal adhesions and these processes and also some intriguing differences.

Original languageEnglish (US)
Pages (from-to)191-231
Number of pages41
JournalInternational Review of Cell and Molecular Biology
Volume287
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Keywords

  • Cadherins
  • Cell adhesion
  • Cell migration and Actin
  • Force generation
  • Integrins
  • Vinculin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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