@inbook{610138a90f33455789fc2894823e93ea,
title = "New Insights into Vinculin Function and Regulation",
abstract = "Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens junctions that is essential for embryonic development. Much is now known regarding the role of vinculin in governing cell-matrix adhesion. In the past decade that the crystal structure of vinculin and the molecular details for how vinculin regulates adhesion events have emerged. The recent data suggests a critical function for vinculin in regulating integrin clustering, force generation, and strength of adhesion. In addition to an important role in cell-matrix adhesion, vinculin is also emerging as a regulator of apoptosis, Shigella entry into host cells, and cadherin-based cell-cell adhesion. A close inspection of this work reveals that there are similarities between vinculin's role in focal adhesions and these processes and also some intriguing differences.",
keywords = "Cadherins, Cell adhesion, Cell migration and Actin, Force generation, Integrins, Vinculin",
author = "Xiao Peng and Nelson, {Elke S.} and Maiers, {Jessica L.} and DeMali, {Kris A.}",
note = "Funding Information: This work is supported by National Institutes of Health Grant # 1K01CA111818 and American Cancer Society Research Scholar Grant # 115274 to K. A. D. and American Heart Association Predoctoral Fellowship # 0910127G to X. P. The UI Interdisciplinary Training Grant in Molecular Biology (NIH Grant #5T32GM073610) supported E. N.",
year = "2011",
doi = "10.1016/B978-0-12-386043-9.00005-0",
language = "English (US)",
series = "International Review of Cell and Molecular Biology",
publisher = "Elsevier Inc.",
pages = "191--231",
booktitle = "International Review of Cell and Molecular Biology",
}