New Insights into Vinculin Function and Regulation

Xiao Peng, Elke S. Nelson, Jessica L. Maiers, Kris A. DeMali

Research output: Chapter in Book/Report/Conference proceedingChapter

93 Scopus citations

Abstract

Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens junctions that is essential for embryonic development. Much is now known regarding the role of vinculin in governing cell-matrix adhesion. In the past decade that the crystal structure of vinculin and the molecular details for how vinculin regulates adhesion events have emerged. The recent data suggests a critical function for vinculin in regulating integrin clustering, force generation, and strength of adhesion. In addition to an important role in cell-matrix adhesion, vinculin is also emerging as a regulator of apoptosis, Shigella entry into host cells, and cadherin-based cell-cell adhesion. A close inspection of this work reveals that there are similarities between vinculin's role in focal adhesions and these processes and also some intriguing differences.

Original languageEnglish (US)
Title of host publicationInternational Review of Cell and Molecular Biology
PublisherElsevier Inc.
Pages191-231
Number of pages41
DOIs
StatePublished - 2011

Publication series

NameInternational Review of Cell and Molecular Biology
Volume287
ISSN (Print)1937-6448

Keywords

  • Cadherins
  • Cell adhesion
  • Cell migration and Actin
  • Force generation
  • Integrins
  • Vinculin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Peng, X., Nelson, E. S., Maiers, J. L., & DeMali, K. A. (2011). New Insights into Vinculin Function and Regulation. In International Review of Cell and Molecular Biology (pp. 191-231). (International Review of Cell and Molecular Biology; Vol. 287). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386043-9.00005-0