New Insights Into the Complex Mutational Landscape of Sézary Syndrome

Abu Sayeef Mirza, Pedro Horna, Jamie K. Teer, Jinming Song, Ratilal Akabari, Mohammad Hussaini, Lubomir Sokol

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Sézary syndrome (SS) is a genetically and clinically distinct entity among cutaneous T-cell lymphomas (CTCL). SS is characterized by more aggressive disease compared to the most common indolent type of CTCL, mycosis fungoides. However, there are limited available genomic data regarding SS. To characterize and expand current mappings of the genomic landscape of CTCL, whole exome sequencing (WES) was performed on peripheral blood samples from seven patients with SS. We detected 21,784 variants, of which 21,140 were novel and 644 were previously described. Filtering revealed 551 nonsynonymous variants among 525 mutated genes−25 recurrent mutations and 1 recurrent variant. Several recurrently mutated genes crucial to pathogenesis pathways, including Janus kinase (JAK)/signal transducers and activators of transcription (STAT), peroxisome proliferator-activated receptors (PPAR), PI3K-serine/threonine protein kinases (AKT), and fibroblast growth factor receptors (FGFR), were identified. Furthermore, genetic mutations spanned both known and novel genes, supporting the idea of a long-tail distribution of mutations in lymphoma. Acknowledging these genetic variants and their affected pathways may inspire future targeted therapies. WES of a limited number of SS patients revealed both novel findings and corroborated complexities of the “long-tail” distribution of previously reported mutations.

Original languageEnglish (US)
Article number514
JournalFrontiers in Oncology
Volume10
DOIs
StatePublished - Apr 21 2020

Keywords

  • Sézary syndrome
  • cutaneous T-cell lymphoma
  • genomics
  • translational oncology
  • whole exome sequencing

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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