New insights into dialysis vascular access: Molecular targets in arteriovenous fistula and arteriovenous graft failure and their potential to improve vascular access outcomes

Timmy Lee, Sanjay Misra

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Vascular access dysfunction remains amajor cause ofmorbidity andmortality in hemodialysis patients. At present there are feweffective therapies for this clinical problem. The poor understanding of the pathobiology that leads to arteriovenous fistula (AVF) and graft (AVG) dysfunction remains a critical barrier to development of novel and effective therapies. However, in recent years we have made substantial progress in our understanding of the mechanisms of vascular access dysfunction. This article presents recent advances and new insights into the pathobiology of AVF and AVGdysfunction and highlights potential therapeutic targets to improve vascular access outcomes.

Original languageEnglish (US)
Pages (from-to)1504-1512
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume11
Issue number8
DOIs
StatePublished - 2016

Keywords

  • Arteriovenous access
  • Arteriovenous fistula
  • Arteriovenous graft

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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