@article{07816642402f4672b26ad0c09f2d4af0,
title = "New insight into coronary endothelial dysfunction: Role of endothelin",
abstract = "The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelial is a potent vasoconstrictor produced by the coronary endothelium and has been implicated In the pathogenesis of coronary endothelial dysfunction. This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.",
author = "Cannan, {Charles R.} and Verghese Mathew and Amir Lerman",
note = "Funding Information: Endothelin is an endothelium-derived peptide that exerts profound vasoconstrictive activity in vitro and in vivo. The role of endothelin as a potent systemic and coronary vasoconstrictor has been well established and extensively reviewed. Although numerous vasoactive substances have an influence on coronary vascular tone, our current understanding of the endothelium suggests From the Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation. Supported in part by the Miami Heart Research Institute, the Bruce and Ruth Rappaport Program in Vascular Biology, and the Mayo Foundation. Submitted for publication Jan. 31, 1997; revision submitted June 18, 1997; accepted June 27, 1997. Reprint requests: Amir Lerman, MD, Division of CardiovascularD is-eases and Internal Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Copyright {\textcopyright} 1998 by Mosby, Inc. 0022-2143/98 $5.00 + 0 5/1/87992",
year = "1998",
month = apr,
doi = "10.1016/S0022-2143(98)90179-2",
language = "English (US)",
volume = "131",
pages = "300--305",
journal = "Journal of Laboratory and Clinical Medicine",
issn = "0022-2143",
publisher = "Mosby Inc.",
number = "4",
}