New insight into coronary endothelial dysfunction: Role of endothelin

Charles R. Cannan, Verghese Mathew, Amir Lerman

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelial is a potent vasoconstrictor produced by the coronary endothelium and has been implicated In the pathogenesis of coronary endothelial dysfunction. This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.

Original languageEnglish (US)
Pages (from-to)300-305
Number of pages6
JournalJournal of Laboratory and Clinical Medicine
Volume131
Issue number4
DOIs
StatePublished - Apr 1998

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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