New Information on the genetics of stroke

James F. Meschia

doi:10.1007/s11910-010-0155-x

New Information on the genetics of stroke

James F. Meschia

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.

Original language	English (US)
Pages (from-to)	35-41
Number of pages	7
Journal	Current neurology and neuroscience reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s11910-010-0155-x
State	Published - Feb 2011

Keywords

CADASIL
CARASIL
Cerebral aneurysm
Cost effectiveness
Fabry disease
Family history
Genetics genomics
Ischemic stroke
Leukoaraiosis
Pharmacogenomics
White matter hyperintensities

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1007/s11910-010-0155-x

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abstract = "Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.",

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KW - CADASIL

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KW - Cost effectiveness

KW - Fabry disease

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KW - Pharmacogenomics

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New Information on the genetics of stroke

Abstract

Keywords

ASJC Scopus subject areas

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