New Information on the genetics of stroke

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalCurrent Neurology and Neuroscience Reports
Volume11
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

Stroke
CADASIL
Fabry Disease
Inborn Genetic Diseases
Pharmacogenetics
Intracranial Aneurysm
Molecular Biology
Ischemia
Phenotype
Genes
Therapeutics
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps
White Matter

Keywords

  • CADASIL
  • CARASIL
  • Cerebral aneurysm
  • Cost effectiveness
  • Fabry disease
  • Family history
  • Genetics genomics
  • Ischemic stroke
  • Leukoaraiosis
  • Pharmacogenomics
  • White matter hyperintensities

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

New Information on the genetics of stroke. / Meschia, James F.

In: Current Neurology and Neuroscience Reports, Vol. 11, No. 1, 02.2011, p. 35-41.

Research output: Contribution to journalArticle

@article{6402a8ea42d64d8b87b1236554f809a9,
title = "New Information on the genetics of stroke",
abstract = "Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.",
keywords = "CADASIL, CARASIL, Cerebral aneurysm, Cost effectiveness, Fabry disease, Family history, Genetics genomics, Ischemic stroke, Leukoaraiosis, Pharmacogenomics, White matter hyperintensities",
author = "Meschia, {James F}",
year = "2011",
month = "2",
doi = "10.1007/s11910-010-0155-x",
language = "English (US)",
volume = "11",
pages = "35--41",
journal = "Current Neurology and Neuroscience Reports",
issn = "1528-4042",
publisher = "Current Medicine Group",
number = "1",

}

TY - JOUR

T1 - New Information on the genetics of stroke

AU - Meschia, James F

PY - 2011/2

Y1 - 2011/2

N2 - Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.

AB - Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.

KW - CADASIL

KW - CARASIL

KW - Cerebral aneurysm

KW - Cost effectiveness

KW - Fabry disease

KW - Family history

KW - Genetics genomics

KW - Ischemic stroke

KW - Leukoaraiosis

KW - Pharmacogenomics

KW - White matter hyperintensities

UR - http://www.scopus.com/inward/record.url?scp=79551569886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551569886&partnerID=8YFLogxK

U2 - 10.1007/s11910-010-0155-x

DO - 10.1007/s11910-010-0155-x

M3 - Article

VL - 11

SP - 35

EP - 41

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

SN - 1528-4042

IS - 1

ER -