New findings from the bipolar collaborative network

Clinical implications for therapeutics

Robert M. Post, Lori L. Altshuler, Mark A Frye, Trisha Suppes, Susan McElroy, Paul E. Keck, Gabriele S. Leverich, Ralph Kupka, Willem A. Nolen, Heinz Grunze

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.

Original languageEnglish (US)
Pages (from-to)489-497
Number of pages9
JournalCurrent Psychiatry Reports
Volume8
Issue number6
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

zonisamide
sibutramine
Tranylcypromine
Bupropion
Sertraline
Weight Loss
Obesity
Placebos
Depression
Therapeutics
modafinil
topiramate
lamotrigine
Venlafaxine Hydrochloride

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

New findings from the bipolar collaborative network : Clinical implications for therapeutics. / Post, Robert M.; Altshuler, Lori L.; Frye, Mark A; Suppes, Trisha; McElroy, Susan; Keck, Paul E.; Leverich, Gabriele S.; Kupka, Ralph; Nolen, Willem A.; Grunze, Heinz.

In: Current Psychiatry Reports, Vol. 8, No. 6, 12.2006, p. 489-497.

Research output: Contribution to journalArticle

Post, RM, Altshuler, LL, Frye, MA, Suppes, T, McElroy, S, Keck, PE, Leverich, GS, Kupka, R, Nolen, WA & Grunze, H 2006, 'New findings from the bipolar collaborative network: Clinical implications for therapeutics', Current Psychiatry Reports, vol. 8, no. 6, pp. 489-497. https://doi.org/10.1007/s11920-006-0056-5
Post, Robert M. ; Altshuler, Lori L. ; Frye, Mark A ; Suppes, Trisha ; McElroy, Susan ; Keck, Paul E. ; Leverich, Gabriele S. ; Kupka, Ralph ; Nolen, Willem A. ; Grunze, Heinz. / New findings from the bipolar collaborative network : Clinical implications for therapeutics. In: Current Psychiatry Reports. 2006 ; Vol. 8, No. 6. pp. 489-497.
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