New findings from the bipolar collaborative network: Clinical implications for therapeutics

Robert M. Post, Lori L. Altshuler, Mark A. Frye, Trisha Suppes, Susan McElroy, Paul E. Keck, Gabriele S. Leverich, Ralph Kupka, Willem A. Nolen, Heinz Grunze

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.

Original languageEnglish (US)
Pages (from-to)489-497
Number of pages9
JournalCurrent psychiatry reports
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2006

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ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Post, R. M., Altshuler, L. L., Frye, M. A., Suppes, T., McElroy, S., Keck, P. E., Leverich, G. S., Kupka, R., Nolen, W. A., & Grunze, H. (2006). New findings from the bipolar collaborative network: Clinical implications for therapeutics. Current psychiatry reports, 8(6), 489-497. https://doi.org/10.1007/s11920-006-0056-5