New developments in the management of relapsed/refractory multiple myeloma – The role of ixazomib

Paul G. Richardson, Shaji Kumar, Jacob P. Laubach, Claudia Paba-Prada, Neeraj Gupta, Deborah Berg, Helgi van de Velde, Philippe Moreau

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Ixazomib is the first oral proteasome inhibitor to be approved, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was on the basis of results from the phase 3, double-blind, placebo-controlled TOURMALINE-MM1 study, which demonstrated a 35% improvement in progression-free survival with the all-oral combination of ixazomib plus lenalidomide–dexamethasone versus lenalidomide–dexamethasone alone (median: 20.6 vs 14.7 months; hazard ratio: 0.74, p=0.012; median follow-up 14.7 months). The addition of ixazomib to the lenalidomide–dexamethasone regimen was associated with limited additional toxicity and had no adverse impact on patient-reported quality of life. Common grade ≥3 adverse events with ixazomib include gastrointestinal adverse events, rash, and thrombocytopenia. Here, we review the efficacy, safety, pharmacokinetics, and patient-reported quality of life data seen with ixazomib, and discuss the role of this oral agent in the treatment of patients with relapsed/ refractory multiple myeloma, including in patients with high-risk cytogenetic abnormalities and those with multiple prior therapies.

Original languageEnglish (US)
Pages (from-to)107-121
Number of pages15
JournalJournal of Blood Medicine
Volume8
DOIs
StatePublished - Aug 22 2017

Keywords

  • Clinical
  • Efficacy
  • Ixazomib
  • Multiple myeloma
  • Pharmacokinetics
  • Proteasome inhibitor
  • Tolerability

ASJC Scopus subject areas

  • Hematology

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