New clinical trials with vitamin D and analogs in renal disease

Rajiv Kumar

doi:10.1038/ki.2011.260

New clinical trials with vitamin D and analogs in renal disease

Rajiv Kumar

Nephrology and Hypertension

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Two new clinical trials highlight refinements in the use of vitamin D and its analogs in the treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD), and the treatment of proteinuria in diabetics. In patients with ESRD, alfacalcidol is as effective as paricalcitol in suppressing parathyroid hormone; the occurrence of hypercalcemia and hyperphosphatemia is infrequent and similar with the two analogs. Oral cholecalciferol reduces albuminuria and urinary transforming growth factor-β1 in patients with type 2 diabetes mellitus and proteinuria.

Original language	English (US)
Pages (from-to)	793-796
Number of pages	4
Journal	Kidney international
Volume	80
Issue number	8
DOIs	https://doi.org/10.1038/ki.2011.260
State	Published - Oct 2 2011

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2011.260

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title = "New clinical trials with vitamin D and analogs in renal disease",

abstract = "Two new clinical trials highlight refinements in the use of vitamin D and its analogs in the treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD), and the treatment of proteinuria in diabetics. In patients with ESRD, alfacalcidol is as effective as paricalcitol in suppressing parathyroid hormone; the occurrence of hypercalcemia and hyperphosphatemia is infrequent and similar with the two analogs. Oral cholecalciferol reduces albuminuria and urinary transforming growth factor-β1 in patients with type 2 diabetes mellitus and proteinuria.",

author = "Rajiv Kumar",

note = "Funding Information: RK's laboratory program is supported by grants from the US National Institutes of Health (DK076829, AR065420, and AR060869), a grant from the Ralph and Marian Falk Foundation, and a grant from Abbott.",

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AB - Two new clinical trials highlight refinements in the use of vitamin D and its analogs in the treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD), and the treatment of proteinuria in diabetics. In patients with ESRD, alfacalcidol is as effective as paricalcitol in suppressing parathyroid hormone; the occurrence of hypercalcemia and hyperphosphatemia is infrequent and similar with the two analogs. Oral cholecalciferol reduces albuminuria and urinary transforming growth factor-β1 in patients with type 2 diabetes mellitus and proteinuria.

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New clinical trials with vitamin D and analogs in renal disease

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