Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans

Muthuvel Jayachandran, Packiasamy Juliet, Arockia Rani, Palaniyappan Arivazhagan, Chinnakkannu Panneerselvam

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Age-associated deficiency of vitamin C contributes to the impaired humoral immune response, which in turn plays a role in the increased risk of illness in old age. Healthy volunteers were given vitamin C supplementation. Neutrophil phagocytic function, complement C3 concentration, and immunoglobulin status were measured at 30, 60, and 90 days. Neutrophil phagocytic function and levels of serum IgG and IgM and leukocytic ascorbate were considerably lower in the aged humans, but these decreases were attenuated by vitamin C supplementation. The level of IgA was not affected by aging. Improved neutrophil phagocytic function and humoral immune response were associated with increased vitamin C status in the aged population and might well contribute to the decreased risk of disease in the aged.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalJournal of Anti-Aging Medicine
Volume3
Issue number1
StatePublished - Mar 2000
Externally publishedYes

Fingerprint

Humoral Immunity
Ascorbic Acid
Neutrophils
Ascorbic Acid Deficiency
Complement C3
Immunoglobulin A
Immunoglobulin M
Immunoglobulins
Healthy Volunteers
Immunoglobulin G
Serum
Population

ASJC Scopus subject areas

  • Aging

Cite this

Jayachandran, M., Juliet, P., Rani, A., Arivazhagan, P., & Panneerselvam, C. (2000). Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans. Journal of Anti-Aging Medicine, 3(1), 37-42.

Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans. / Jayachandran, Muthuvel; Juliet, Packiasamy; Rani, Arockia; Arivazhagan, Palaniyappan; Panneerselvam, Chinnakkannu.

In: Journal of Anti-Aging Medicine, Vol. 3, No. 1, 03.2000, p. 37-42.

Research output: Contribution to journalArticle

Jayachandran, M, Juliet, P, Rani, A, Arivazhagan, P & Panneerselvam, C 2000, 'Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans', Journal of Anti-Aging Medicine, vol. 3, no. 1, pp. 37-42.
Jayachandran, Muthuvel ; Juliet, Packiasamy ; Rani, Arockia ; Arivazhagan, Palaniyappan ; Panneerselvam, Chinnakkannu. / Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans. In: Journal of Anti-Aging Medicine. 2000 ; Vol. 3, No. 1. pp. 37-42.
@article{fdf137d18d2542688cd23f070f06db15,
title = "Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans",
abstract = "Age-associated deficiency of vitamin C contributes to the impaired humoral immune response, which in turn plays a role in the increased risk of illness in old age. Healthy volunteers were given vitamin C supplementation. Neutrophil phagocytic function, complement C3 concentration, and immunoglobulin status were measured at 30, 60, and 90 days. Neutrophil phagocytic function and levels of serum IgG and IgM and leukocytic ascorbate were considerably lower in the aged humans, but these decreases were attenuated by vitamin C supplementation. The level of IgA was not affected by aging. Improved neutrophil phagocytic function and humoral immune response were associated with increased vitamin C status in the aged population and might well contribute to the decreased risk of disease in the aged.",
author = "Muthuvel Jayachandran and Packiasamy Juliet and Arockia Rani and Palaniyappan Arivazhagan and Chinnakkannu Panneerselvam",
year = "2000",
month = "3",
language = "English (US)",
volume = "3",
pages = "37--42",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",
number = "1",

}

TY - JOUR

T1 - Neutrophil phagocytic function and humoral immune response with reference to ascorbate supplementation in aging humans

AU - Jayachandran, Muthuvel

AU - Juliet, Packiasamy

AU - Rani, Arockia

AU - Arivazhagan, Palaniyappan

AU - Panneerselvam, Chinnakkannu

PY - 2000/3

Y1 - 2000/3

N2 - Age-associated deficiency of vitamin C contributes to the impaired humoral immune response, which in turn plays a role in the increased risk of illness in old age. Healthy volunteers were given vitamin C supplementation. Neutrophil phagocytic function, complement C3 concentration, and immunoglobulin status were measured at 30, 60, and 90 days. Neutrophil phagocytic function and levels of serum IgG and IgM and leukocytic ascorbate were considerably lower in the aged humans, but these decreases were attenuated by vitamin C supplementation. The level of IgA was not affected by aging. Improved neutrophil phagocytic function and humoral immune response were associated with increased vitamin C status in the aged population and might well contribute to the decreased risk of disease in the aged.

AB - Age-associated deficiency of vitamin C contributes to the impaired humoral immune response, which in turn plays a role in the increased risk of illness in old age. Healthy volunteers were given vitamin C supplementation. Neutrophil phagocytic function, complement C3 concentration, and immunoglobulin status were measured at 30, 60, and 90 days. Neutrophil phagocytic function and levels of serum IgG and IgM and leukocytic ascorbate were considerably lower in the aged humans, but these decreases were attenuated by vitamin C supplementation. The level of IgA was not affected by aging. Improved neutrophil phagocytic function and humoral immune response were associated with increased vitamin C status in the aged population and might well contribute to the decreased risk of disease in the aged.

UR - http://www.scopus.com/inward/record.url?scp=1642618114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642618114&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:1642618114

VL - 3

SP - 37

EP - 42

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

IS - 1

ER -