Neurotrophin Receptor Signaling

R. S. Kenchappa, B. D. Carter

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The neurotrophins, nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 and -4, are a family of highly homologous proteins regulating neuronal survival and differentiation during the development of the vertebrate nervous system. They act through binding two types of receptors, a family of tyrosine kinase receptors, referred to as the Trks, and a member of the tumor necrosis factor receptor superfamily, p75NTR. This article discusses the mechanisms by which the receptors mediate the responses to neurotrophin or proneurotrophin binding.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages241-246
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • Apoptosis
  • BDNF
  • Cell survival
  • Gamma-secretase
  • Neurotrophins
  • NGF
  • P75NTR
  • Phosphorylation
  • Proneurotrophins
  • Receptor
  • Signal transduction
  • Trk receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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