Neurotoxicity of pyridoxine analogs is related to coenzyme structure

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In very high doses, pyridoxine is neurotoxic in humans and other animals. Using morphometry and a model system of dorsal root ganglion neurons in culture, we found that several analogs of pyridoxine were neurotoxic in vitro. Those that may be converted into active coenzymes- pyridoxal, pyridoxine, and pyridoxamine- were almost equal in, toxicity. Pyridoxic acid, which is not active, was nontoxic. Pyridoxamine 5-phosphate, which cannot enter cells, also was nontoxic. Several hypotheses that link coenzyme function to toxic effect are described.

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalNeurochemical Pathology
Volume3
Issue number3
DOIs
StatePublished - Sep 1 1985

Keywords

  • Neurotoxicity, of pyridoxine analogs
  • culture, of dorsal root ganglion explant
  • dorsal root ganglion explant culture, and pyridoxine
  • explant culture, of dorsal root ganglion, and pyridoxine
  • morphometry, in tissue culture
  • pyridoxine, neurotoxicity in vitro
  • substrate inhibition

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology

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