Abstract
In very high doses, pyridoxine is neurotoxic in humans and other animals. Using morphometry and a model system of dorsal root ganglion neurons in culture, we found that several analogs of pyridoxine were neurotoxic in vitro. Those that may be converted into active coenzymes- pyridoxal, pyridoxine, and pyridoxamine- were almost equal in, toxicity. Pyridoxic acid, which is not active, was nontoxic. Pyridoxamine 5-phosphate, which cannot enter cells, also was nontoxic. Several hypotheses that link coenzyme function to toxic effect are described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-167 |
| Number of pages | 9 |
| Journal | Neurochemical Pathology |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1985 |
Keywords
- Neurotoxicity, of pyridoxine analogs
- culture, of dorsal root ganglion explant
- dorsal root ganglion explant culture, and pyridoxine
- explant culture, of dorsal root ganglion, and pyridoxine
- morphometry, in tissue culture
- pyridoxine, neurotoxicity in vitro
- substrate inhibition
ASJC Scopus subject areas
- Molecular Biology
- Clinical Neurology