Neurotoxicity of pyridoxine analogs is related to coenzyme structure

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In very high doses, pyridoxine is neurotoxic in humans and other animals. Using morphometry and a model system of dorsal root ganglion neurons in culture, we found that several analogs of pyridoxine were neurotoxic in vitro. Those that may be converted into active coenzymes- pyridoxal, pyridoxine, and pyridoxamine- were almost equal in, toxicity. Pyridoxic acid, which is not active, was nontoxic. Pyridoxamine 5-phosphate, which cannot enter cells, also was nontoxic. Several hypotheses that link coenzyme function to toxic effect are described.

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalNeurochemical Pathology
Volume3
Issue number3
DOIs
StatePublished - Sep 1985

Fingerprint

Pyridoxine
Coenzymes
Pyridoxic Acid
Pyridoxamine
Pyridoxal
Poisons
Spinal Ganglia
Neurons

Keywords

  • culture, of dorsal root ganglion explant
  • dorsal root ganglion explant culture, and pyridoxine
  • explant culture, of dorsal root ganglion, and pyridoxine
  • morphometry, in tissue culture
  • Neurotoxicity, of pyridoxine analogs
  • pyridoxine, neurotoxicity in vitro
  • substrate inhibition

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology

Cite this

Neurotoxicity of pyridoxine analogs is related to coenzyme structure. / Windebank, Anthony John.

In: Neurochemical Pathology, Vol. 3, No. 3, 09.1985, p. 159-167.

Research output: Contribution to journalArticle

@article{4934caa2e3a14352ba827994c0d9bad0,
title = "Neurotoxicity of pyridoxine analogs is related to coenzyme structure",
abstract = "In very high doses, pyridoxine is neurotoxic in humans and other animals. Using morphometry and a model system of dorsal root ganglion neurons in culture, we found that several analogs of pyridoxine were neurotoxic in vitro. Those that may be converted into active coenzymes- pyridoxal, pyridoxine, and pyridoxamine- were almost equal in, toxicity. Pyridoxic acid, which is not active, was nontoxic. Pyridoxamine 5-phosphate, which cannot enter cells, also was nontoxic. Several hypotheses that link coenzyme function to toxic effect are described.",
keywords = "culture, of dorsal root ganglion explant, dorsal root ganglion explant culture, and pyridoxine, explant culture, of dorsal root ganglion, and pyridoxine, morphometry, in tissue culture, Neurotoxicity, of pyridoxine analogs, pyridoxine, neurotoxicity in vitro, substrate inhibition",
author = "Windebank, {Anthony John}",
year = "1985",
month = "9",
doi = "10.1007/BF02834268",
language = "English (US)",
volume = "3",
pages = "159--167",
journal = "Journal of Molecular Neuroscience",
issn = "0895-8696",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - Neurotoxicity of pyridoxine analogs is related to coenzyme structure

AU - Windebank, Anthony John

PY - 1985/9

Y1 - 1985/9

N2 - In very high doses, pyridoxine is neurotoxic in humans and other animals. Using morphometry and a model system of dorsal root ganglion neurons in culture, we found that several analogs of pyridoxine were neurotoxic in vitro. Those that may be converted into active coenzymes- pyridoxal, pyridoxine, and pyridoxamine- were almost equal in, toxicity. Pyridoxic acid, which is not active, was nontoxic. Pyridoxamine 5-phosphate, which cannot enter cells, also was nontoxic. Several hypotheses that link coenzyme function to toxic effect are described.

AB - In very high doses, pyridoxine is neurotoxic in humans and other animals. Using morphometry and a model system of dorsal root ganglion neurons in culture, we found that several analogs of pyridoxine were neurotoxic in vitro. Those that may be converted into active coenzymes- pyridoxal, pyridoxine, and pyridoxamine- were almost equal in, toxicity. Pyridoxic acid, which is not active, was nontoxic. Pyridoxamine 5-phosphate, which cannot enter cells, also was nontoxic. Several hypotheses that link coenzyme function to toxic effect are described.

KW - culture, of dorsal root ganglion explant

KW - dorsal root ganglion explant culture, and pyridoxine

KW - explant culture, of dorsal root ganglion, and pyridoxine

KW - morphometry, in tissue culture

KW - Neurotoxicity, of pyridoxine analogs

KW - pyridoxine, neurotoxicity in vitro

KW - substrate inhibition

UR - http://www.scopus.com/inward/record.url?scp=0022127728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022127728&partnerID=8YFLogxK

U2 - 10.1007/BF02834268

DO - 10.1007/BF02834268

M3 - Article

VL - 3

SP - 159

EP - 167

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

SN - 0895-8696

IS - 3

ER -