Neurotensin receptor type 1 regulates ethanol intoxication and consumption in mice

Moonnoh R. Lee, David J. Hinton, Jane Y. Song, Kyung Won Lee, Christopher Choo, Heidi Johng, Sencan S. Unal, Elliott Richelson, Doo Sup Choi

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Neurotensin receptor type 1 (NTS1) is known to mediate a variety of biological functions of neurotensin (NT) in the central nervous system. In this study, we found that NTS1 null mice displayed decreased sensitivity to the ataxic effect of ethanol on the rotarod and increased ethanol consumption when given a free choice between ethanol and tap water containing bottles. Interestingly, the administration of NT69L, a brain-permeable NT analog, increased ethanol sensitivity in wild-type littermates but had no such effect in NTS1 null mice, suggesting that NTS1 contributes to NT-mediated ethanol intoxication. Furthermore, the daily treatment of NT69L, for 4 consecutive days, significantly reduced alcohol preference and consumption in wild-type littermates but had no such effects in NTS1 null mice in a two-bottle drinking experiment. Our study provides evidence for possible pharmacological roles of NT69L in which it increases sensitivity to the ataxic effect, and decreases voluntary consumption, of ethanol. Our study also demonstrates NTS1-mediated behavioral effects of NT69L. Therefore, our findings will be useful for understanding some aspects of alcoholism as well as to develop novel pharmacological therapeutic options for humans.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume95
Issue number2
DOIs
StatePublished - Apr 2010

Keywords

  • Alcohol
  • Consumption
  • Intoxication
  • NT69L
  • Neurotensin
  • Sensitivity

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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  • Cite this

    Lee, M. R., Hinton, D. J., Song, J. Y., Lee, K. W., Choo, C., Johng, H., Unal, S. S., Richelson, E., & Choi, D. S. (2010). Neurotensin receptor type 1 regulates ethanol intoxication and consumption in mice. Pharmacology Biochemistry and Behavior, 95(2), 235-241. https://doi.org/10.1016/j.pbb.2010.01.012