Neurotensin agonists as an alternative to antipsychotics

Mona Boules, Paul Fredrickson, Elliott Richelson

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Neurotensin (NT) is a 13 amino acid neuropeptide that is found in the central nervous system and in the gastrointestinal tract. In brain, this peptide is prominently associated anatomically with dopaminergic, as well as other neurotransmitter systems. Based on animal studies, already decades old, researchers have hypothesised that NT receptor agonists will have antipsychotic properties in patients. However, to date no one has obtained a nonpeptide NT receptor agonist. Therefore, there has been great interest in obtaining peptide analogues of NT, that, unlike NT resist degradation by peptidases and cross the blood-brain barrier, yet have the pharmacological characteristics of native NT, for therapeutic use in the treatment of schizophrenia, as well as other neuropsychiatric diseases such as Parkinson's disease and addiction to psychostimulants. In this review, we present the rationale for development of NT receptor agonists for treatment of certain central nervous system diseases, as well as a review of those peptide agonists that are in early stages of development.

Original languageEnglish (US)
Pages (from-to)359-369
Number of pages11
JournalExpert Opinion on Investigational Drugs
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2005

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Keywords

  • NT69L
  • Neuropeptides
  • Parkinson's disease
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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