TY - JOUR
T1 - Neurostimulation as a Method of Treatment and a Preventive Measure in Canine Drug-Resistant Epilepsy
T2 - Current State and Future Prospects
AU - Nowakowska, Marta
AU - Üçal, Muammer
AU - Charalambous, Marios
AU - Bhatti, Sofie F.M.
AU - Denison, Timothy
AU - Meller, Sebastian
AU - Worrell, Gregory A.
AU - Potschka, Heidrun
AU - Volk, Holger A.
N1 - Funding Information:
MN and MÜ are financed from ZK 17 Zukunftskolleg provided by the Austrian Science Fund (FWF – Der Wissenschaftsfonds). GW has received funding from National Institutes of Health (U01-NS073557, R01-NS92882, and UH2/3-NS95495) and the Epilepsy Foundation Epilepsy Innovation Institute My Seizure Gauge. This open access publication was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - 491094227 Open Access Publication Costs and the University of Veterinary Medicine Hannover, Foundation.
Publisher Copyright:
Copyright © 2022 Nowakowska, Üçal, Charalambous, Bhatti, Denison, Meller, Worrell, Potschka and Volk.
PY - 2022/6/16
Y1 - 2022/6/16
N2 - Modulation of neuronal activity for seizure control using various methods of neurostimulation is a rapidly developing field in epileptology, especially in treatment of refractory epilepsy. Promising results in human clinical practice, such as diminished seizure burden, reduced incidence of sudden unexplained death in epilepsy, and improved quality of life has brought neurostimulation into the focus of veterinary medicine as a therapeutic option. This article provides a comprehensive review of available neurostimulation methods for seizure management in drug-resistant epilepsy in canine patients. Recent progress in non-invasive modalities, such as repetitive transcranial magnetic stimulation and transcutaneous vagus nerve stimulation is highlighted. We further discuss potential future advances and their plausible application as means for preventing epileptogenesis in dogs.
AB - Modulation of neuronal activity for seizure control using various methods of neurostimulation is a rapidly developing field in epileptology, especially in treatment of refractory epilepsy. Promising results in human clinical practice, such as diminished seizure burden, reduced incidence of sudden unexplained death in epilepsy, and improved quality of life has brought neurostimulation into the focus of veterinary medicine as a therapeutic option. This article provides a comprehensive review of available neurostimulation methods for seizure management in drug-resistant epilepsy in canine patients. Recent progress in non-invasive modalities, such as repetitive transcranial magnetic stimulation and transcutaneous vagus nerve stimulation is highlighted. We further discuss potential future advances and their plausible application as means for preventing epileptogenesis in dogs.
KW - deep brain stimulation
KW - dogs
KW - drug-resistant epilepsy
KW - epileptogenesis
KW - seizure
KW - transcranial magnetic stimulation
KW - vagus nerve stimulation
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U2 - 10.3389/fvets.2022.889561
DO - 10.3389/fvets.2022.889561
M3 - Review article
AN - SCOPUS:85133546456
SN - 2297-1769
VL - 9
JO - Frontiers in Veterinary Science
JF - Frontiers in Veterinary Science
M1 - 889561
ER -