Neurosarcoidosis

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Involvement of the nervous system by sarcoidosis is defined by pathologic proof either directly in the nervous system or systemically with appropriate findings consistent with sarcoidosis on neuroimaging and spinal fluid examinations. CNS sarcoidosis can present without systemic manifestations. Chronic meningitis is the most common clinical presentation, but cranial neuropathy, myelopathy, peripheral neuropathy, and myopathy are all possible. MRI imaging and gadolinium enhancement of the CNS is important for diagnosis. Spinal fluid abnormalities can be used as markers of disease activity during therapy. Biopsy of abnormal lymph node, lung, skin, meninges, or brain confirms the diagnosis. Conjunctival biopsy is a reasonable site for blind biopsy in CNS cases. Corticosteroids remain the mainstay of therapy, but the use of tumor necrosis factor α-antagonists shows significant promise in treatment of refractory CNS sarcoidosis cases.

Original languageEnglish (US)
Pages (from-to)181-196
Number of pages16
JournalCONTINUUM Lifelong Learning in Neurology
Volume14
Issue number1
DOIs
StatePublished - Feb 1 2008

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Sarcoidosis
Biopsy
Cranial Nerve Diseases
Meninges
Spinal Cord Diseases
Gadolinium
Peripheral Nervous System Diseases
Muscular Diseases
Meningitis
Neuroimaging
Nervous System
Adrenal Cortex Hormones
Tumor Necrosis Factor-alpha
Lymph Nodes
Lung
Skin
Brain
Therapeutics
Neurosarcoidosis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Clinical Neurology

Cite this

Neurosarcoidosis. / Aksamit, Allen Jr.

In: CONTINUUM Lifelong Learning in Neurology, Vol. 14, No. 1, 01.02.2008, p. 181-196.

Research output: Contribution to journalReview article

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