Neuropsychological outcomes following stereotactic laser amygdalohippocampectomy

Melanie R.F. Greenway, John A Lucas, Anteneh Feyissa, Sanjeet Grewal, Robert E. Wharen, William O. Tatum

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective The objective was to analyze neuropsychological testing data from 15 patients before and after stereotactic laser ablation surgery for temporal lobe epilepsy and to describe the seizure outcomes after stereotactic laser ablation surgery. Methods A retrospective review of 15 patients who underwent stereotactic laser ablation and who also underwent neuropsychological testing before and after surgery was performed. Verbal and visual memory was assessed in all 15 patients using California Verbal Learning Test and Wechsler Memory Scale IV. Naming was assessed in 9 of 15 patients using the Boston Naming Test. Statistical analysis was performed to determine clinically significant changes using previously validated reliable change indices and proprietary Advanced Clinical Solutions software. Seizure outcome data were evaluated using Engel classification. Results Postsurgery neuropsychological evaluation demonstrated that all 15 patients experienced at least 1 clinically significant decline in either verbal or visual memory. Ten patients in this series, including five with dominant-hemisphere surgery, demonstrated decline in delayed memory for narrative information (Logical Memory II). By contrast, the Boston Naming Test demonstrated more favorable results after surgery. Two of nine patients demonstrated a clinically significant increase in naming ability, and only one of nine patients demonstrated a clinically significant decline in naming ability. With at least 6 months of follow-up after surgery, 33% reported seizure freedom. Conclusion Stereotactic laser ablation can result in clinically significant and meaningful decline in verbal and visual memory when comparing patients to their own presurgical baseline. Naming ability, conversely, is much less likely to be impacted by stereotactic laser ablation and may improve after the procedure.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalEpilepsy and Behavior
Volume75
DOIs
StatePublished - Oct 1 2017

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Laser Therapy
Lasers
Aptitude
Seizures
Repression (Psychology)
Wechsler Scales
Verbal Learning
Temporal Lobe Epilepsy
Software

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Neuropsychological outcomes following stereotactic laser amygdalohippocampectomy. / Greenway, Melanie R.F.; Lucas, John A; Feyissa, Anteneh; Grewal, Sanjeet; Wharen, Robert E.; Tatum, William O.

In: Epilepsy and Behavior, Vol. 75, 01.10.2017, p. 50-55.

Research output: Contribution to journalArticle

Greenway, Melanie R.F. ; Lucas, John A ; Feyissa, Anteneh ; Grewal, Sanjeet ; Wharen, Robert E. ; Tatum, William O. / Neuropsychological outcomes following stereotactic laser amygdalohippocampectomy. In: Epilepsy and Behavior. 2017 ; Vol. 75. pp. 50-55.
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