Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor

Julie A Fields, A. I. Tröster, S. P. Woods, C. I. Higginson, S. B. Wilkinson, K. E. Lyons, W. C. Koller, R. Pahwa

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objectives: To evaluate the one year cognitive, mood state, and quality of life (QoL) outcomes of unilateral thalamic deep brain stimulation (DBS) for essential tremor (ET). Methods: 40 patients diagnosed with ET completed comprehensive neuropsychological assessments about one month before and three and 12 months after DBS electrode implantation. Data were subjected to multivariate analyses, and significant results were further analysed using univariate techniques. Results: Analyses revealed statistically significant improvements on a cognitive screening measure and in aspects of fine visuomotor and visuoperceptual functions, verbal memory, mood state, and QoL. No group-wise declines in cognition were observed, but more patients showed declines than improvements on language and visual memory tests. Semantic verbal fluency declined significantly in four (10%) of the patients. In these four patients, diminished lexical verbal fluency was present at baseline. Conclusion: Cognitive, mood, and QoL outcomes after one year of DBS for ET are favourable; there were no overall deleterious effects on cognition, and DBS was accompanied by a significant reduction in anxiety and improvements in quality of life. However, preoperative verbal fluency diminution may predispose to further fluency declines after DBS.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume74
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Essential Tremor
Deep Brain Stimulation
Quality of Life
Cognition
Semantics
Electrodes
Language
Multivariate Analysis
Anxiety

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor. / Fields, Julie A; Tröster, A. I.; Woods, S. P.; Higginson, C. I.; Wilkinson, S. B.; Lyons, K. E.; Koller, W. C.; Pahwa, R.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 74, No. 3, 01.03.2003, p. 305-311.

Research output: Contribution to journalArticle

Fields, Julie A ; Tröster, A. I. ; Woods, S. P. ; Higginson, C. I. ; Wilkinson, S. B. ; Lyons, K. E. ; Koller, W. C. ; Pahwa, R. / Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor. In: Journal of Neurology Neurosurgery and Psychiatry. 2003 ; Vol. 74, No. 3. pp. 305-311.
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