Neuropsychological and quality of life changes following unilateral thalamic deep brain stimulation in Parkinson's disease: A one-year follow-up

S. P. Woods, J. A. Fields, K. E. Lyons, W. C. Koller, S. B. Wilkinson, R. Pahwa, A. I. Tröster

Research output: Contribution to journalArticle

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Background. The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in patients with intractable Parkinson's disease (PD) have not heretofore been described. Method. Six patients diagnosed with PD underwent unilateral DBS implantation into a veri(r)ed thalamic VIM nucleus target. Participants completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery. Findings. Compared to their presurgical scores, PD patients exhibited signi(r)cant improvement on measures of conceptualization, verbal memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests. Interpretation. These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation in patients with PD.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalActa Neurochirurgica
Issue number12
StatePublished - Dec 1 2001



  • Deep brain stimulation
  • Neuropsychology
  • Parkinson's disease
  • Quality of life

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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