Neuropsychological and quality of life changes following unilateral thalamic deep brain stimulation in Parkinson's disease: A one-year follow-up

S. P. Woods; J. A. Fields; K. E. Lyons; W. C. Koller; S. B. Wilkinson; R. Pahwa; A. I. Tröster

doi:10.1007/s007010100024

Neuropsychological and quality of life changes following unilateral thalamic deep brain stimulation in Parkinson's disease: A one-year follow-up

S. P. Woods, J. A. Fields, K. E. Lyons, W. C. Koller, S. B. Wilkinson, R. Pahwa, A. I. Tröster

Psychiatry and Psychology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background. The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in patients with intractable Parkinson's disease (PD) have not heretofore been described. Method. Six patients diagnosed with PD underwent unilateral DBS implantation into a veri(r)ed thalamic VIM nucleus target. Participants completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery. Findings. Compared to their presurgical scores, PD patients exhibited signi(r)cant improvement on measures of conceptualization, verbal memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests. Interpretation. These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation in patients with PD.

Original language	English (US)
Pages (from-to)	1273-1278
Number of pages	6
Journal	Acta Neurochirurgica
Volume	143
Issue number	12
DOIs	https://doi.org/10.1007/s007010100024
State	Published - 2001

Keywords

Deep brain stimulation
Neuropsychology
Parkinson's disease
Quality of life

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1007/s007010100024

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title = "Neuropsychological and quality of life changes following unilateral thalamic deep brain stimulation in Parkinson's disease: A one-year follow-up",

abstract = "Background. The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in patients with intractable Parkinson's disease (PD) have not heretofore been described. Method. Six patients diagnosed with PD underwent unilateral DBS implantation into a veri(r)ed thalamic VIM nucleus target. Participants completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery. Findings. Compared to their presurgical scores, PD patients exhibited signi(r)cant improvement on measures of conceptualization, verbal memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests. Interpretation. These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation in patients with PD.",

keywords = "Deep brain stimulation, Neuropsychology, Parkinson's disease, Quality of life",

author = "Woods, {S. P.} and Fields, {J. A.} and Lyons, {K. E.} and Koller, {W. C.} and Wilkinson, {S. B.} and R. Pahwa and Tr{\"o}ster, {A. I.}",

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T1 - Neuropsychological and quality of life changes following unilateral thalamic deep brain stimulation in Parkinson's disease

T2 - A one-year follow-up

AU - Woods, S. P.

AU - Fields, J. A.

AU - Lyons, K. E.

AU - Koller, W. C.

AU - Wilkinson, S. B.

AU - Pahwa, R.

AU - Tröster, A. I.

PY - 2001

Y1 - 2001

N2 - Background. The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in patients with intractable Parkinson's disease (PD) have not heretofore been described. Method. Six patients diagnosed with PD underwent unilateral DBS implantation into a veri(r)ed thalamic VIM nucleus target. Participants completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery. Findings. Compared to their presurgical scores, PD patients exhibited signi(r)cant improvement on measures of conceptualization, verbal memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests. Interpretation. These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation in patients with PD.

AB - Background. The long-term neuropsychological and quality of life (QOL) outcomes of unilateral thalamic deep brain stimulation (DBS) in patients with intractable Parkinson's disease (PD) have not heretofore been described. Method. Six patients diagnosed with PD underwent unilateral DBS implantation into a veri(r)ed thalamic VIM nucleus target. Participants completed presurgical neuropsychological evaluation and follow-up assessment at approximately one year postsurgery. Findings. Compared to their presurgical scores, PD patients exhibited signi(r)cant improvement on measures of conceptualization, verbal memory, emotional adjustment, and QOL at one-year follow-up. A few nominal declines were observed across the battery of tests. Interpretation. These data provide preliminary support for the long-term neurocognitive safety and QOL improvements following thalamic stimulation in patients with PD.

KW - Deep brain stimulation

KW - Neuropsychology

KW - Parkinson's disease

KW - Quality of life

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Neuropsychological and quality of life changes following unilateral thalamic deep brain stimulation in Parkinson's disease: A one-year follow-up

Abstract

Keywords

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