Neuropsychiatric symptoms in Alzheimer's disease

Past progress and anticipation of the future

Yonas Endale Geda, Lon S. Schneider, Laura N. Gitlin, David S. Miller, Gwenn S. Smith, Joanne Bell, Jovier Evans, Michael Lee, Anton Porsteinsson, Krista L. Lanctôt, Paul B. Rosenberg, David L. Sultzer, Paul T. Francis, Henry Brodaty, Prasad P. Padala, Chiadikaobi U. Onyike, Luis Agüera Ortiz, Sonia Ancoli-Israel, Donald L. Bliwise, Jennifer L. Martin & 11 others Michael V. Vitiello, Kristine Yaffe, Phyllis C. Zee, Nathan Herrmann, Robert A. Sweet, Clive Ballard, Ni A. Khin, Cara Alfaro, Patrick S. Murray, Susan Schultz, Constantine G. Lyketsos

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalAlzheimer's and Dementia
Volume9
Issue number5
DOIs
StatePublished - Sep 2013

Fingerprint

Alzheimer Disease
Jealousy
Research
Living Wills
Apathy
Neurobehavioral Manifestations
Delusions
Psychotic Disorders
Sleep
Depression
Therapeutics

Keywords

  • Agitation/aggression
  • Alzheimer's disease
  • Apathy
  • Behavioral and psychological symptoms of dementia
  • Delusions
  • Dementia
  • Depression
  • Hallucinations
  • Mild behavioral impairment
  • Mild cognitive impairment
  • Neuropsychiatric symptoms
  • Psychosis
  • Sleep disorders

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Geda, Y. E., Schneider, L. S., Gitlin, L. N., Miller, D. S., Smith, G. S., Bell, J., ... Lyketsos, C. G. (2013). Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future. Alzheimer's and Dementia, 9(5), 602-608. https://doi.org/10.1016/j.jalz.2012.12.001

Neuropsychiatric symptoms in Alzheimer's disease : Past progress and anticipation of the future. / Geda, Yonas Endale; Schneider, Lon S.; Gitlin, Laura N.; Miller, David S.; Smith, Gwenn S.; Bell, Joanne; Evans, Jovier; Lee, Michael; Porsteinsson, Anton; Lanctôt, Krista L.; Rosenberg, Paul B.; Sultzer, David L.; Francis, Paul T.; Brodaty, Henry; Padala, Prasad P.; Onyike, Chiadikaobi U.; Ortiz, Luis Agüera; Ancoli-Israel, Sonia; Bliwise, Donald L.; Martin, Jennifer L.; Vitiello, Michael V.; Yaffe, Kristine; Zee, Phyllis C.; Herrmann, Nathan; Sweet, Robert A.; Ballard, Clive; Khin, Ni A.; Alfaro, Cara; Murray, Patrick S.; Schultz, Susan; Lyketsos, Constantine G.

In: Alzheimer's and Dementia, Vol. 9, No. 5, 09.2013, p. 602-608.

Research output: Contribution to journalArticle

Geda, YE, Schneider, LS, Gitlin, LN, Miller, DS, Smith, GS, Bell, J, Evans, J, Lee, M, Porsteinsson, A, Lanctôt, KL, Rosenberg, PB, Sultzer, DL, Francis, PT, Brodaty, H, Padala, PP, Onyike, CU, Ortiz, LA, Ancoli-Israel, S, Bliwise, DL, Martin, JL, Vitiello, MV, Yaffe, K, Zee, PC, Herrmann, N, Sweet, RA, Ballard, C, Khin, NA, Alfaro, C, Murray, PS, Schultz, S & Lyketsos, CG 2013, 'Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future', Alzheimer's and Dementia, vol. 9, no. 5, pp. 602-608. https://doi.org/10.1016/j.jalz.2012.12.001
Geda, Yonas Endale ; Schneider, Lon S. ; Gitlin, Laura N. ; Miller, David S. ; Smith, Gwenn S. ; Bell, Joanne ; Evans, Jovier ; Lee, Michael ; Porsteinsson, Anton ; Lanctôt, Krista L. ; Rosenberg, Paul B. ; Sultzer, David L. ; Francis, Paul T. ; Brodaty, Henry ; Padala, Prasad P. ; Onyike, Chiadikaobi U. ; Ortiz, Luis Agüera ; Ancoli-Israel, Sonia ; Bliwise, Donald L. ; Martin, Jennifer L. ; Vitiello, Michael V. ; Yaffe, Kristine ; Zee, Phyllis C. ; Herrmann, Nathan ; Sweet, Robert A. ; Ballard, Clive ; Khin, Ni A. ; Alfaro, Cara ; Murray, Patrick S. ; Schultz, Susan ; Lyketsos, Constantine G. / Neuropsychiatric symptoms in Alzheimer's disease : Past progress and anticipation of the future. In: Alzheimer's and Dementia. 2013 ; Vol. 9, No. 5. pp. 602-608.
@article{78a5d24bce494366bdd03970e19c699b,
title = "Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future",
abstract = "Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.",
keywords = "Agitation/aggression, Alzheimer's disease, Apathy, Behavioral and psychological symptoms of dementia, Delusions, Dementia, Depression, Hallucinations, Mild behavioral impairment, Mild cognitive impairment, Neuropsychiatric symptoms, Psychosis, Sleep disorders",
author = "Geda, {Yonas Endale} and Schneider, {Lon S.} and Gitlin, {Laura N.} and Miller, {David S.} and Smith, {Gwenn S.} and Joanne Bell and Jovier Evans and Michael Lee and Anton Porsteinsson and Lanct{\^o}t, {Krista L.} and Rosenberg, {Paul B.} and Sultzer, {David L.} and Francis, {Paul T.} and Henry Brodaty and Padala, {Prasad P.} and Onyike, {Chiadikaobi U.} and Ortiz, {Luis Ag{\"u}era} and Sonia Ancoli-Israel and Bliwise, {Donald L.} and Martin, {Jennifer L.} and Vitiello, {Michael V.} and Kristine Yaffe and Zee, {Phyllis C.} and Nathan Herrmann and Sweet, {Robert A.} and Clive Ballard and Khin, {Ni A.} and Cara Alfaro and Murray, {Patrick S.} and Susan Schultz and Lyketsos, {Constantine G.}",
year = "2013",
month = "9",
doi = "10.1016/j.jalz.2012.12.001",
language = "English (US)",
volume = "9",
pages = "602--608",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Neuropsychiatric symptoms in Alzheimer's disease

T2 - Past progress and anticipation of the future

AU - Geda, Yonas Endale

AU - Schneider, Lon S.

AU - Gitlin, Laura N.

AU - Miller, David S.

AU - Smith, Gwenn S.

AU - Bell, Joanne

AU - Evans, Jovier

AU - Lee, Michael

AU - Porsteinsson, Anton

AU - Lanctôt, Krista L.

AU - Rosenberg, Paul B.

AU - Sultzer, David L.

AU - Francis, Paul T.

AU - Brodaty, Henry

AU - Padala, Prasad P.

AU - Onyike, Chiadikaobi U.

AU - Ortiz, Luis Agüera

AU - Ancoli-Israel, Sonia

AU - Bliwise, Donald L.

AU - Martin, Jennifer L.

AU - Vitiello, Michael V.

AU - Yaffe, Kristine

AU - Zee, Phyllis C.

AU - Herrmann, Nathan

AU - Sweet, Robert A.

AU - Ballard, Clive

AU - Khin, Ni A.

AU - Alfaro, Cara

AU - Murray, Patrick S.

AU - Schultz, Susan

AU - Lyketsos, Constantine G.

PY - 2013/9

Y1 - 2013/9

N2 - Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.

AB - Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.

KW - Agitation/aggression

KW - Alzheimer's disease

KW - Apathy

KW - Behavioral and psychological symptoms of dementia

KW - Delusions

KW - Dementia

KW - Depression

KW - Hallucinations

KW - Mild behavioral impairment

KW - Mild cognitive impairment

KW - Neuropsychiatric symptoms

KW - Psychosis

KW - Sleep disorders

UR - http://www.scopus.com/inward/record.url?scp=84883557180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883557180&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2012.12.001

DO - 10.1016/j.jalz.2012.12.001

M3 - Article

VL - 9

SP - 602

EP - 608

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 5

ER -