TY - JOUR
T1 - Neuropsychiatric correlates and treatment of lenticulostriatal diseases
T2 - A review of the literature and overview of research opportunities in Huntington's, Wilson's, and Fahr's diseases. A report of the ANPA Committee on Research
AU - Lauterbach, Edward C.
AU - Cummings, Jeffrey L.
AU - Duffy, James
AU - Coffey, C. Edward
AU - Kaufer, Daniel
AU - Lovell, Mark
AU - Malloy, Paul
AU - Reeve, Alison
AU - Royall, Donald R.
AU - Rummans, Teresa A.
AU - Salloway, Stephen P.
PY - 1998
Y1 - 1998
N2 - This report reviews clinical neuropsychiatric findings and opportunities for research in Huntington's, Wilson's, and Fahr's diseases. Consistent, systematic methodology is lacking among neuropsychiatric studies in these lenticulostriatal diseases. Systematic cross-sectional and longitudinal assessments are needed to ascertain the prevalence of psychiatric disorders as a function of disease course. Preliminary synthesis of existing data suggests the following heuristic relationships in these diseases: depression with parkinsonian states; personality changes with caudate or putamen disease; psychosis, impulsivity, and sexual disorders with caudate disease; dementia and mania with caudate and pallidal diseases; and compulsions with pallidal disease. Correlation of neuropsychiatric findings with disease stage, clinical signs, and radiologic, metabolic, physiologic, and pathologic markers of disease will add to our understanding of these conditions.
AB - This report reviews clinical neuropsychiatric findings and opportunities for research in Huntington's, Wilson's, and Fahr's diseases. Consistent, systematic methodology is lacking among neuropsychiatric studies in these lenticulostriatal diseases. Systematic cross-sectional and longitudinal assessments are needed to ascertain the prevalence of psychiatric disorders as a function of disease course. Preliminary synthesis of existing data suggests the following heuristic relationships in these diseases: depression with parkinsonian states; personality changes with caudate or putamen disease; psychosis, impulsivity, and sexual disorders with caudate disease; dementia and mania with caudate and pallidal diseases; and compulsions with pallidal disease. Correlation of neuropsychiatric findings with disease stage, clinical signs, and radiologic, metabolic, physiologic, and pathologic markers of disease will add to our understanding of these conditions.
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U2 - 10.1176/jnp.10.3.249
DO - 10.1176/jnp.10.3.249
M3 - Review article
C2 - 9706533
AN - SCOPUS:20244371466
SN - 0895-0172
VL - 10
SP - 249
EP - 266
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -