Neuropsychiatric correlates and treatment of lenticulostriatal diseases

A review of the literature and overview of research opportunities in Huntington's, Wilson's, and Fahr's diseases. A report of the ANPA Committee on Research

Edward C. Lauterbach, Jeffrey L. Cummings, James Duffy, C. Edward Coffey, Daniel Kaufer, Mark Lovell, Paul Malloy, Alison Reeve, Donald R. Royall, Teresa A. Rummans, Stephen P. Salloway

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

This report reviews clinical neuropsychiatric findings and opportunities for research in Huntington's, Wilson's, and Fahr's diseases. Consistent, systematic methodology is lacking among neuropsychiatric studies in these lenticulostriatal diseases. Systematic cross-sectional and longitudinal assessments are needed to ascertain the prevalence of psychiatric disorders as a function of disease course. Preliminary synthesis of existing data suggests the following heuristic relationships in these diseases: depression with parkinsonian states; personality changes with caudate or putamen disease; psychosis, impulsivity, and sexual disorders with caudate disease; dementia and mania with caudate and pallidal diseases; and compulsions with pallidal disease. Correlation of neuropsychiatric findings with disease stage, clinical signs, and radiologic, metabolic, physiologic, and pathologic markers of disease will add to our understanding of these conditions.

Original languageEnglish (US)
Pages (from-to)249-266
Number of pages18
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume10
Issue number3
StatePublished - Jun 1998
Externally publishedYes

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Hepatolenticular Degeneration
Research
Impulsive Behavior
Putamen
Bipolar Disorder
Psychotic Disorders
Psychiatry
Personality
Dementia
Depression

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Neuropsychiatric correlates and treatment of lenticulostriatal diseases : A review of the literature and overview of research opportunities in Huntington's, Wilson's, and Fahr's diseases. A report of the ANPA Committee on Research. / Lauterbach, Edward C.; Cummings, Jeffrey L.; Duffy, James; Coffey, C. Edward; Kaufer, Daniel; Lovell, Mark; Malloy, Paul; Reeve, Alison; Royall, Donald R.; Rummans, Teresa A.; Salloway, Stephen P.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 10, No. 3, 06.1998, p. 249-266.

Research output: Contribution to journalArticle

Lauterbach, Edward C. ; Cummings, Jeffrey L. ; Duffy, James ; Coffey, C. Edward ; Kaufer, Daniel ; Lovell, Mark ; Malloy, Paul ; Reeve, Alison ; Royall, Donald R. ; Rummans, Teresa A. ; Salloway, Stephen P. / Neuropsychiatric correlates and treatment of lenticulostriatal diseases : A review of the literature and overview of research opportunities in Huntington's, Wilson's, and Fahr's diseases. A report of the ANPA Committee on Research. In: Journal of Neuropsychiatry and Clinical Neurosciences. 1998 ; Vol. 10, No. 3. pp. 249-266.
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