Neuropathy symptom profile in health, motor neuron disease, diabetic neuropathy, and amyloidosis

Peter James Dyck, Jeannine Karnes, Peter C. O’Brien, Carol J. Swanson

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

We developed a true-or-false questionnaire with several hundred questions about symptoms encountered in peripheral neuropathy, to be scored by optical reader and computer. Responses were grouped into scales called “Neuropathy,” “Weakness,” “Sensory,” “Autonomic,” and subsets of these. Profiles in health were estimated for each scale based on responses from 300 healthy subjects 15 to 65 years old. The sensitivity and specificity of the scales were tested in patients with motor neuron disease, amyloidosis, or diabetes, with or without neuropathy. The questionnaire was useful in detecting neuropathy and staging severity, and in recognizing patterns that may have diagnostic implications.

Original languageEnglish (US)
Pages (from-to)1300-1308
Number of pages9
JournalNeurology
Volume36
Issue number10
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Clinical Neurology

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