Neuropathology of Parkinson’s disease after focused ultrasound thalamotomy

Shunsuke Koga; Mariam Ishaque; W. Jeffrey Elias; Binit B. Shah; Aya Murakami; Dennis W. Dickson

doi:10.1038/s41531-022-00319-6

Neuropathology of Parkinson’s disease after focused ultrasound thalamotomy

Shunsuke Koga, Mariam Ishaque, W. Jeffrey Elias, Binit B. Shah, Aya Murakami, Dennis W. Dickson

Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

Focused ultrasound (FUS) thalamotomy is an emerging treatment for tremor-dominant Parkinson’s disease (PD). We report the first postmortem neuropathologic study of FUS thalamotomy in a 68-year-old man with tremor-dominant PD, which was performed seven months before he died. Although the peak voxel temperature at the target was <54 °C, his tremor improved on intraoperative and postoperative assessments. Additionally, postoperative MRI demonstrated a thalamic lesion. Lewy body-related pathology consistent with PD was detected. There was also a 5-mm lesion in the ventral lateral thalamus characterized by demyelination and neuropil loss, with many lipid-laden macrophages, but no lymphocytic infiltrates and relatively preserved neurons and axons. Additional pathological assessments after FUS thalamotomy are needed to determine if the observed brain changes are typical of this procedure.

Original language	English (US)
Article number	59
Journal	npj Parkinson's Disease
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41531-022-00319-6
State	Published - Dec 2022

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1038/s41531-022-00319-6

Cite this

@article{42d544d19a45450084ee1816decd1d27,

title = "Neuropathology of Parkinson{\textquoteright}s disease after focused ultrasound thalamotomy",

abstract = "Focused ultrasound (FUS) thalamotomy is an emerging treatment for tremor-dominant Parkinson{\textquoteright}s disease (PD). We report the first postmortem neuropathologic study of FUS thalamotomy in a 68-year-old man with tremor-dominant PD, which was performed seven months before he died. Although the peak voxel temperature at the target was <54 °C, his tremor improved on intraoperative and postoperative assessments. Additionally, postoperative MRI demonstrated a thalamic lesion. Lewy body-related pathology consistent with PD was detected. There was also a 5-mm lesion in the ventral lateral thalamus characterized by demyelination and neuropil loss, with many lipid-laden macrophages, but no lymphocytic infiltrates and relatively preserved neurons and axons. Additional pathological assessments after FUS thalamotomy are needed to determine if the observed brain changes are typical of this procedure.",

author = "Shunsuke Koga and Mariam Ishaque and {Jeffrey Elias}, W. and Shah, {Binit B.} and Aya Murakami and Dickson, {Dennis W.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41531-022-00319-6",

language = "English (US)",

volume = "8",

journal = "npj Parkinson's Disease",

issn = "2373-8057",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Neuropathology of Parkinson’s disease after focused ultrasound thalamotomy

AU - Koga, Shunsuke

AU - Ishaque, Mariam

AU - Jeffrey Elias, W.

AU - Shah, Binit B.

AU - Murakami, Aya

AU - Dickson, Dennis W.

PY - 2022/12

Y1 - 2022/12

N2 - Focused ultrasound (FUS) thalamotomy is an emerging treatment for tremor-dominant Parkinson’s disease (PD). We report the first postmortem neuropathologic study of FUS thalamotomy in a 68-year-old man with tremor-dominant PD, which was performed seven months before he died. Although the peak voxel temperature at the target was <54 °C, his tremor improved on intraoperative and postoperative assessments. Additionally, postoperative MRI demonstrated a thalamic lesion. Lewy body-related pathology consistent with PD was detected. There was also a 5-mm lesion in the ventral lateral thalamus characterized by demyelination and neuropil loss, with many lipid-laden macrophages, but no lymphocytic infiltrates and relatively preserved neurons and axons. Additional pathological assessments after FUS thalamotomy are needed to determine if the observed brain changes are typical of this procedure.

AB - Focused ultrasound (FUS) thalamotomy is an emerging treatment for tremor-dominant Parkinson’s disease (PD). We report the first postmortem neuropathologic study of FUS thalamotomy in a 68-year-old man with tremor-dominant PD, which was performed seven months before he died. Although the peak voxel temperature at the target was <54 °C, his tremor improved on intraoperative and postoperative assessments. Additionally, postoperative MRI demonstrated a thalamic lesion. Lewy body-related pathology consistent with PD was detected. There was also a 5-mm lesion in the ventral lateral thalamus characterized by demyelination and neuropil loss, with many lipid-laden macrophages, but no lymphocytic infiltrates and relatively preserved neurons and axons. Additional pathological assessments after FUS thalamotomy are needed to determine if the observed brain changes are typical of this procedure.

UR - http://www.scopus.com/inward/record.url?scp=85130018307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85130018307&partnerID=8YFLogxK

U2 - 10.1038/s41531-022-00319-6

DO - 10.1038/s41531-022-00319-6

M3 - Article

AN - SCOPUS:85130018307

SN - 2373-8057

VL - 8

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

M1 - 59

ER -

Neuropathology of Parkinson’s disease after focused ultrasound thalamotomy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this