Neuropathology of Parkinson's disease

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Introduction The clinical features of Parkinson's disease (PD) are bradykinesia, rigidity, tremor and postural instability, but increasingly recognized are non-motor manifestations, such as anosmia, autonomic dysfunction, sleep disorders, psychiatric symptoms (e.g. depression) and cognitive impairment. The typical clinical features of PD reflect well-known pathology in the dopaminergic nigrostriatal system, while extra-nigral pathology accounts for many of the non-motor features of PD. As will be subsequently discussed, the most characteristic pathologic feature of PD is neurodegeneration with Lewy body (LB) formation, but it must be acknowledged that occasionally other pathologic processes cause clinical features typical of PD. In particular, some cases of multiple system atrophy (MSA) or even progressive supranuclear palsy (PSP) may be clinically mistaken for PD (Bower et al., 2002). More problematic are cases of PD with juvenile onset or those associated with an autosomal recessive pattern of inheritance, such as cases with Parkin and DJ-1 mutations (see below), in which LBs may not be present. Other early onset familial cases present with atypical clinical features such as early dementia and psychosis, which are not characteristic of typical PD (Gwinn-Hardy et al. 2000). Another diagnostic challenge is the relationship of cognitive dysfunction in PD to concurrent Alzheimer's disease and dementia with Lewy bodies (DLB) (McKeith et al. 1996). As in all neurologic syndromes, the clinical presentation reflects the neuroanatomy of the disease process more than the nature of the underlying pathology.

Original languageEnglish (US)
Title of host publicationNeurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics
PublisherCambridge University Press
Pages575-585
Number of pages11
Volume9780521811668
ISBN (Print)9780511544873, 052181166X, 9780521811668
DOIs
StatePublished - Jan 1 2005

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Parkinson Disease
Lewy Bodies
Pathology
Alzheimer Disease
Olfaction Disorders
Progressive Supranuclear Palsy
Multiple System Atrophy
Neuroanatomy
Inheritance Patterns
Hypokinesia
Neuropathology
Parkinsonian Disorders
Tremor
Substantia Nigra
Pathologic Processes
Psychotic Disorders
Nervous System
Psychiatry
Dementia
Depression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dickson, D. W. (2005). Neuropathology of Parkinson's disease. In Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics (Vol. 9780521811668, pp. 575-585). Cambridge University Press. https://doi.org/10.1017/CBO9780511544873.040

Neuropathology of Parkinson's disease. / Dickson, Dennis W.

Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. Vol. 9780521811668 Cambridge University Press, 2005. p. 575-585.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dickson, DW 2005, Neuropathology of Parkinson's disease. in Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. vol. 9780521811668, Cambridge University Press, pp. 575-585. https://doi.org/10.1017/CBO9780511544873.040
Dickson DW. Neuropathology of Parkinson's disease. In Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. Vol. 9780521811668. Cambridge University Press. 2005. p. 575-585 https://doi.org/10.1017/CBO9780511544873.040
Dickson, Dennis W. / Neuropathology of Parkinson's disease. Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. Vol. 9780521811668 Cambridge University Press, 2005. pp. 575-585
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