Neuropathology of non-motor features of Parkinson disease

Dennis W Dickson, Hiroshige Fujishiro, Carolyn Orr, Anthony DelleDonne, Keith Anthony Josephs, Roberta Frigerio, Melinda Burnett, Joseph E Parisi, Kevin J. Klos, J. Eric Ahlskog

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Non-motor manifestations of Parkinson disease (PD) are common and some may actually antedate motor dysfunction. Extrapyramidal signs in PD are tightly linked to striatonigral dopaminergic denervation associated with neuronal loss and Lewy bodies in the residual neurons of the substantia nigra. Lewy bodies composed of abnormal α-synuclein are the histologic hallmark of PD, and their presence beyond midbrain dopaminergic neurons is considered to be the pathologic substrate of many, if not all, of the non-motor manifestations of PD. We review the pathologic correlates of autonomic dysfunction (cardiac and gastrointestinal), hyposmia, depression, rapid eye movement behavior disorder and dementia in PD For each non-motor clinical feature there is strong evidence to suggest a role for α-synuclein pathology, lending further support for the notion that PD is a multisystem α-synucleinopathy.

Original languageEnglish (US)
JournalParkinsonism and Related Disorders
Volume15
Issue numberSUPPL. 3
DOIs
StatePublished - Dec 2009

Fingerprint

Parkinson Disease
Synucleins
Lewy Bodies
Ocular Motility Disorders
Dopaminergic Neurons
REM Sleep
Denervation
Substantia Nigra
Mesencephalon
Mental Disorders
Dementia
Neuropathology
Depression
Pathology
Neurons

Keywords

  • Autonomic
  • Dementia
  • Hyposmia
  • Rapid eye movement sleep behavior disorder
  • Synucleinopathy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Neuropathology of non-motor features of Parkinson disease. / Dickson, Dennis W; Fujishiro, Hiroshige; Orr, Carolyn; DelleDonne, Anthony; Josephs, Keith Anthony; Frigerio, Roberta; Burnett, Melinda; Parisi, Joseph E; Klos, Kevin J.; Ahlskog, J. Eric.

In: Parkinsonism and Related Disorders, Vol. 15, No. SUPPL. 3, 12.2009.

Research output: Contribution to journalArticle

Dickson, DW, Fujishiro, H, Orr, C, DelleDonne, A, Josephs, KA, Frigerio, R, Burnett, M, Parisi, JE, Klos, KJ & Ahlskog, JE 2009, 'Neuropathology of non-motor features of Parkinson disease', Parkinsonism and Related Disorders, vol. 15, no. SUPPL. 3. https://doi.org/10.1016/S1353-8020(09)70769-2
Dickson, Dennis W ; Fujishiro, Hiroshige ; Orr, Carolyn ; DelleDonne, Anthony ; Josephs, Keith Anthony ; Frigerio, Roberta ; Burnett, Melinda ; Parisi, Joseph E ; Klos, Kevin J. ; Ahlskog, J. Eric. / Neuropathology of non-motor features of Parkinson disease. In: Parkinsonism and Related Disorders. 2009 ; Vol. 15, No. SUPPL. 3.
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