Neuropathology of multiple sclerosis

Bogdan F Gh Popescu, Claudia F Lucchinetti

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Significant progress in our understanding and treatment of multiple sclerosis (MS) has been enabled by remarkable advances in genetics, expression profiling, proteomics, bioinformatics, and systems-biology tools. However, the successful application of these approaches to advancing the field is contingent upon an appreciation that MS is biologically diverse and histologically complex. MS pathology differs based on stage of demyelinating activity, topographical region, structural, and immunopathological features, disease phase, age at onset, course, and duration. This chapter will review the dynamic neuropathology of MS and discuss its clinical and pathogenic implications.

Original languageEnglish (US)
Title of host publicationMultiple Sclerosis: A Mechanistic View
PublisherElsevier Inc.
Pages181-200
Number of pages20
ISBN (Electronic)9780128010051
ISBN (Print)9780128007631
DOIs
StatePublished - Jan 1 2015

Keywords

  • Axonal injury
  • Cortical lesion
  • Demyelination
  • Inflammation
  • Oxidative damage
  • Plaque
  • Remyelination

ASJC Scopus subject areas

  • Medicine(all)

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    Popescu, B. F. G., & Lucchinetti, C. F. (2015). Neuropathology of multiple sclerosis. In Multiple Sclerosis: A Mechanistic View (pp. 181-200). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800763-1.00009-9