Neuropathology of Alzheimer's Disease and its Variants

Charles Duyckaerts, Dennis W Dickson

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Alzheimer's disease is defined by parenchymal deposits of Aβ peptide, and by intracellular accumulation of tau protein, accompanied by cerebral atrophy, particularly affecting the hippocampus and parahippocampal gyrus, with variable ventricular dilation. Aβ peptide, cleaved from the amyloid precursor protein (APP) by β-and γ-secretase enzymes, accumulates mainly extracellularly, as diffuse or focal deposits. Aβ peptide is also the main constituent of cerebral amyloid angiopathy, thought to be due to deficits in clearance of Aβ in the vessel walls. Tau protein accumulates in neurons as neurofibrillary tangles (neuronal cell body), neuropil threads (mainly dendrites) and degenerating neurites of the corona of the neuritic plaque. Synaptic and neuronal losses are important pathogenetic mechanisms, but difficult to routinely assess. Neuroinflammation could also play an important role. In additon to pathology associated with neuropathology of Alzheimer's disease and its variants, its differential diagnosis is also considered.

Original languageEnglish (US)
Title of host publicationNeurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition
PublisherWiley-Blackwell
Pages62-91
Number of pages30
ISBN (Print)9781405196932
DOIs
StatePublished - Sep 21 2011

Fingerprint

tau Proteins
Alzheimer Disease
Peptides
Neuropil Threads
Cerebral Amyloid Angiopathy
Parahippocampal Gyrus
Amyloid Precursor Protein Secretases
Neurofibrillary Tangles
Amyloid Plaques
Neurites
Dendrites
Atrophy
Dilatation
Hippocampus
Differential Diagnosis
Pathology
Neurons
Enzymes
Neuropathology
Cell Body

Keywords

  • Aβ peptide
  • Alzheimer's disease
  • Cerebral amyloid angiopathy
  • Neurofibrillary tangle
  • Neuropil threads
  • Senile plaque
  • Tau protein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Duyckaerts, C., & Dickson, D. W. (2011). Neuropathology of Alzheimer's Disease and its Variants. In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition (pp. 62-91). Wiley-Blackwell. https://doi.org/10.1002/9781444341256.ch10

Neuropathology of Alzheimer's Disease and its Variants. / Duyckaerts, Charles; Dickson, Dennis W.

Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. Wiley-Blackwell, 2011. p. 62-91.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duyckaerts, C & Dickson, DW 2011, Neuropathology of Alzheimer's Disease and its Variants. in Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. Wiley-Blackwell, pp. 62-91. https://doi.org/10.1002/9781444341256.ch10
Duyckaerts C, Dickson DW. Neuropathology of Alzheimer's Disease and its Variants. In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. Wiley-Blackwell. 2011. p. 62-91 https://doi.org/10.1002/9781444341256.ch10
Duyckaerts, Charles ; Dickson, Dennis W. / Neuropathology of Alzheimer's Disease and its Variants. Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. Wiley-Blackwell, 2011. pp. 62-91
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