Neuropathology and pathogenesis of dementia with lewy bodies

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Dementia with Lewy bodies (DLB) is a clinical syndrome characterized by mid-to-late life dementia associated with visual hallucinations, parkinsonism and a fluctuating clinical course (McKeith et al, 2004). In this discussion, the term Lewy body disease (LBD) is used to refer to the pathological process associated with neuronal cytoplasmic inclusions first described by Lewy (Dickson, 2002a). As is true for all clinical neurological syndromes, the pathological substrate of DLB is not exclusively a single disease process. For example, parkinsonism, which is the clinical syndrome characterized by bradykinesia, rigidity and resting tremor, has a number of distinct pathological substrates, including LBD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) (Dickson, 2002b). These disorders share progressive neuronal loss and gliosis in the dopaminergic neurons of the pars compacta of the substantia nigra, which leads to the striatal dopaminergic deficiencies that cause the extrapyramidal parkinsonian syndrome (Fig. 11.1c). Given that one of the cardinal clinical features of DLB is parkinsonism, it can be predicted that the pathological substrate for this aspect of DLB might be heterogeneous. Indeed, autopsy studies of prospectively diagnosed patients with DLB occasionally have identified neurofibrillary tangle pathology, consistent with PSP, in the substantia nigra rather than Lewy bodies (McKeith et al, 2000).

Original languageEnglish (US)
Title of host publicationDementia with Lewy Bodies
Subtitle of host publicationand Parkinson's Disease Dementia
PublisherCRC Press
Pages149-166
Number of pages18
ISBN (Electronic)9780203313909
ISBN (Print)1841843954, 9781841843957
StatePublished - Jan 1 2005

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Lewy Body Disease
Parkinsonian Disorders
Progressive Supranuclear Palsy
Dementia
Multiple System Atrophy
Lewy Bodies
Corpus Striatum
Hypokinesia
Neurofibrillary Tangles
Gliosis
Hallucinations
Dopaminergic Neurons
Inclusion Bodies
Tremor
Substantia Nigra
Pathologic Processes
Neuropathology
Autopsy
Pathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dickson, D. W. (2005). Neuropathology and pathogenesis of dementia with lewy bodies. In Dementia with Lewy Bodies: and Parkinson's Disease Dementia (pp. 149-166). CRC Press.

Neuropathology and pathogenesis of dementia with lewy bodies. / Dickson, Dennis W.

Dementia with Lewy Bodies: and Parkinson's Disease Dementia. CRC Press, 2005. p. 149-166.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dickson, DW 2005, Neuropathology and pathogenesis of dementia with lewy bodies. in Dementia with Lewy Bodies: and Parkinson's Disease Dementia. CRC Press, pp. 149-166.
Dickson DW. Neuropathology and pathogenesis of dementia with lewy bodies. In Dementia with Lewy Bodies: and Parkinson's Disease Dementia. CRC Press. 2005. p. 149-166
Dickson, Dennis W. / Neuropathology and pathogenesis of dementia with lewy bodies. Dementia with Lewy Bodies: and Parkinson's Disease Dementia. CRC Press, 2005. pp. 149-166
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