Neuropathological changes in early HIV‐1 dementia

Justin C. McArthur; P. Scott Becker; Joseph E. Parisi; Bruce Trapp; Ola A. Selnes; David R. Cornblath; Janaki Balakrishnan; John W. Griffin; Donald Price

doi:10.1002/ana.410260516

Neuropathological changes in early HIV‐1 dementia

Justin C. McArthur, P. Scott Becker, Joseph E. Parisi, Bruce Trapp, Ola A. Selnes, David R. Cornblath, Janaki Balakrishnan, John W. Griffin, Donald Price

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Early pathological abnormalities in human immunodeficiency virus (HIV‐1)–related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV‐1–related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study. Within 4 months he died of massive epistaxis, and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation, multinucleated giant cells, and brain atrophy.

Original language	English (US)
Pages (from-to)	681-684
Number of pages	4
Journal	Annals of neurology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1002/ana.410260516
State	Published - Nov 1989

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.410260516

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AU - McArthur, Justin C.

AU - Becker, P. Scott

AU - Parisi, Joseph E.

AU - Trapp, Bruce

AU - Selnes, Ola A.

AU - Cornblath, David R.

AU - Balakrishnan, Janaki

AU - Griffin, John W.

AU - Price, Donald

PY - 1989/11

Y1 - 1989/11

N2 - Early pathological abnormalities in human immunodeficiency virus (HIV‐1)–related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV‐1–related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study. Within 4 months he died of massive epistaxis, and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation, multinucleated giant cells, and brain atrophy.

AB - Early pathological abnormalities in human immunodeficiency virus (HIV‐1)–related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV‐1–related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study. Within 4 months he died of massive epistaxis, and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation, multinucleated giant cells, and brain atrophy.

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Neuropathological changes in early HIV‐1 dementia

Abstract

ASJC Scopus subject areas

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