Neuropathological basis of nonmotor manifestations of Parkinson's disease

Charles Howard Adler, Thomas G. Beach

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy-type α-synucleinopathy present outside the nigro-striatal pathway and that this may underlie these nonmotor manifestations. This review discusses neuropathological findings that may underlie nonmotor symptoms that either predate motor findings or occur as the disease progresses.

Original languageEnglish (US)
JournalMovement Disorders
DOIs
StateAccepted/In press - 2016

Fingerprint

Parkinson Disease
Corpus Striatum
Prednisolone
Autopsy
Clinical Studies

Keywords

  • Nonmotor signs
  • Parkinson's disease
  • Synuclein

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Neuropathological basis of nonmotor manifestations of Parkinson's disease. / Adler, Charles Howard; Beach, Thomas G.

In: Movement Disorders, 2016.

Research output: Contribution to journalArticle

@article{70874dd4806a4b268274473595eb69f8,
title = "Neuropathological basis of nonmotor manifestations of Parkinson's disease",
abstract = "Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy-type α-synucleinopathy present outside the nigro-striatal pathway and that this may underlie these nonmotor manifestations. This review discusses neuropathological findings that may underlie nonmotor symptoms that either predate motor findings or occur as the disease progresses.",
keywords = "Nonmotor signs, Parkinson's disease, Synuclein",
author = "Adler, {Charles Howard} and Beach, {Thomas G.}",
year = "2016",
doi = "10.1002/mds.26605",
language = "English (US)",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Neuropathological basis of nonmotor manifestations of Parkinson's disease

AU - Adler, Charles Howard

AU - Beach, Thomas G.

PY - 2016

Y1 - 2016

N2 - Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy-type α-synucleinopathy present outside the nigro-striatal pathway and that this may underlie these nonmotor manifestations. This review discusses neuropathological findings that may underlie nonmotor symptoms that either predate motor findings or occur as the disease progresses.

AB - Nonmotor manifestations of Parkinson's disease (PD) can begin well before motor PD begins. It is now clear, from clinical and autopsy studies, that there is significant Lewy-type α-synucleinopathy present outside the nigro-striatal pathway and that this may underlie these nonmotor manifestations. This review discusses neuropathological findings that may underlie nonmotor symptoms that either predate motor findings or occur as the disease progresses.

KW - Nonmotor signs

KW - Parkinson's disease

KW - Synuclein

UR - http://www.scopus.com/inward/record.url?scp=84962755420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962755420&partnerID=8YFLogxK

U2 - 10.1002/mds.26605

DO - 10.1002/mds.26605

M3 - Article

C2 - 27030013

AN - SCOPUS:84962755420

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

ER -