TY - JOUR
T1 - Neuropathological assessment of Parkinson's disease
T2 - refining the diagnostic criteria
AU - Dickson, Dennis W.
AU - Braak, Heiko
AU - Duda, John E.
AU - Duyckaerts, Charles
AU - Gasser, Thomas
AU - Halliday, Glenda M.
AU - Hardy, John
AU - Leverenz, James B.
AU - Del Tredici, Kelly
AU - Wszolek, Zbigniew K.
AU - Litvan, Irene
PY - 2009/12
Y1 - 2009/12
N2 - To date, there have been few systematic attempts to provide a standard operating procedure for the neuropathological diagnosis of Parkinson's disease (PD). Pathological examination cannot classify the clinical syndrome with certainty; therefore, the neuropathological diagnosis is, at best, a probability statement. The neuropathological diagnosis of parkinsonism has become increasingly based on fundamental molecular underpinnings, with recognition that the genetics of parkinsonism is heterogeneous and includes disorders that are associated with and without Lewy bodies. The advent of α-synuclein immunohistochemistry has substantially improved the ability to identify Lewy pathology, particularly cortical Lewy bodies and smaller aggregates within processes and the neuropil. In this Review we discuss the diagnostic criteria for the neuropathological assessment of PD. These criteria are provisional and need to be validated through an iterative process that could help with their refinement. Additionally, we suggest future directions for neuropathology research on PD.
AB - To date, there have been few systematic attempts to provide a standard operating procedure for the neuropathological diagnosis of Parkinson's disease (PD). Pathological examination cannot classify the clinical syndrome with certainty; therefore, the neuropathological diagnosis is, at best, a probability statement. The neuropathological diagnosis of parkinsonism has become increasingly based on fundamental molecular underpinnings, with recognition that the genetics of parkinsonism is heterogeneous and includes disorders that are associated with and without Lewy bodies. The advent of α-synuclein immunohistochemistry has substantially improved the ability to identify Lewy pathology, particularly cortical Lewy bodies and smaller aggregates within processes and the neuropil. In this Review we discuss the diagnostic criteria for the neuropathological assessment of PD. These criteria are provisional and need to be validated through an iterative process that could help with their refinement. Additionally, we suggest future directions for neuropathology research on PD.
UR - http://www.scopus.com/inward/record.url?scp=71849092190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71849092190&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(09)70238-8
DO - 10.1016/S1474-4422(09)70238-8
M3 - Review article
C2 - 19909913
AN - SCOPUS:71849092190
SN - 1474-4422
VL - 8
SP - 1150
EP - 1157
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 12
ER -