Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and has the highest propensity to manifest as metastatic disease. Recent characterizations of the genetic signature of ccRCC have revealed several factors correlated with tumor cell migration and invasion; however, the specific events driving malignancy are not well defined. Furthermore, there remains a lack of targeted therapies that result in long-term, sustainable response in patients with metastatic disease. We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccRCC primary tumors and metastases, and that it contributes to tumor cell viability and promotes cell migration through its interaction with the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. We propose NPTX2 as a novel molecular target for therapy for patients with ccRCC diagnosed with or at risk of developing metastatic disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4796-4810 |
| Number of pages | 15 |
| Journal | Cancer Research |
| Volume | 74 |
| Issue number | 17 |
| DOIs | |
| State | Published - Sep 1 2014 |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4. / Von Roemeling, Christina A.; Radisky, Derek C; Marlow, Laura A.; Cooper, Simon J.; Grebe, Stefan K.; Anastasiadis, Panagiotis Z; Tun, Han W; Copland, John A III.
In: Cancer Research, Vol. 74, No. 17, 01.09.2014, p. 4796-4810.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4
AU - Von Roemeling, Christina A.
AU - Radisky, Derek C
AU - Marlow, Laura A.
AU - Cooper, Simon J.
AU - Grebe, Stefan K.
AU - Anastasiadis, Panagiotis Z
AU - Tun, Han W
AU - Copland, John A III
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and has the highest propensity to manifest as metastatic disease. Recent characterizations of the genetic signature of ccRCC have revealed several factors correlated with tumor cell migration and invasion; however, the specific events driving malignancy are not well defined. Furthermore, there remains a lack of targeted therapies that result in long-term, sustainable response in patients with metastatic disease. We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccRCC primary tumors and metastases, and that it contributes to tumor cell viability and promotes cell migration through its interaction with the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. We propose NPTX2 as a novel molecular target for therapy for patients with ccRCC diagnosed with or at risk of developing metastatic disease.
AB - Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and has the highest propensity to manifest as metastatic disease. Recent characterizations of the genetic signature of ccRCC have revealed several factors correlated with tumor cell migration and invasion; however, the specific events driving malignancy are not well defined. Furthermore, there remains a lack of targeted therapies that result in long-term, sustainable response in patients with metastatic disease. We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccRCC primary tumors and metastases, and that it contributes to tumor cell viability and promotes cell migration through its interaction with the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4. We propose NPTX2 as a novel molecular target for therapy for patients with ccRCC diagnosed with or at risk of developing metastatic disease.
UR - http://www.scopus.com/inward/record.url?scp=84907059429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907059429&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-14-0210
DO - 10.1158/0008-5472.CAN-14-0210
M3 - Article
C2 - 24962026
AN - SCOPUS:84907059429
VL - 74
SP - 4796
EP - 4810
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 17
ER -