TY - JOUR
T1 - Neuronal nitric oxide synthase expression in developing and adult human CNS
AU - Downen, Martha
AU - Zhao, Meng Liang
AU - Lee, Paul
AU - Weidenheim, Karen M.
AU - Dickson, Dennis W.
AU - Lee, Sunhee C.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1999/1
Y1 - 1999/1
N2 - Neuronal nitric oxide synthase (nNOS) is constitutively expressed by subpopulations of neurons in the CNS and is involved in neurotransmission, learning and memory, and neuronal injury. While the distribution of nNOS neurons has been characterized in the rodent CNS, the expression in human brain has not been well documented. We determined the expression of nNOS in second trimester human fetal and adult brain. In second trimester fetal brain, the nNOS neurons are concentrated in the developing cerebral cortex at the subplate zone and in layer VI, the striatum, and in certain brainstem nuclei. The nNOS neurons are sparsely distributed in the hippocampus, and virtually absent in the cerebellar cortex. The nNOS neurons in the subplate zone extend their processes radially, suggesting a developmental role, perhaps in guidance. The number and distribution of NADPH diaphorase-positive neurons corresponds to that of the nNOS neurons. While the distribution of nNOS neurons in the adult brain is similar to that found in fetal brain, the overall density is lower in the adult. The highest density' of nNOS neurons is found in the striatum followed by the neocortex. A region-specific role for nNOS neurons in human brain and a potential developmental role for nNOS in the cerebral cortex are suggested by these data.
AB - Neuronal nitric oxide synthase (nNOS) is constitutively expressed by subpopulations of neurons in the CNS and is involved in neurotransmission, learning and memory, and neuronal injury. While the distribution of nNOS neurons has been characterized in the rodent CNS, the expression in human brain has not been well documented. We determined the expression of nNOS in second trimester human fetal and adult brain. In second trimester fetal brain, the nNOS neurons are concentrated in the developing cerebral cortex at the subplate zone and in layer VI, the striatum, and in certain brainstem nuclei. The nNOS neurons are sparsely distributed in the hippocampus, and virtually absent in the cerebellar cortex. The nNOS neurons in the subplate zone extend their processes radially, suggesting a developmental role, perhaps in guidance. The number and distribution of NADPH diaphorase-positive neurons corresponds to that of the nNOS neurons. While the distribution of nNOS neurons in the adult brain is similar to that found in fetal brain, the overall density is lower in the adult. The highest density' of nNOS neurons is found in the striatum followed by the neocortex. A region-specific role for nNOS neurons in human brain and a potential developmental role for nNOS in the cerebral cortex are suggested by these data.
KW - Adult
KW - CNS
KW - Fetal
KW - Human
KW - NADPH diaphorase
KW - Nitric oxide synthase
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U2 - 10.1097/00005072-199901000-00002
DO - 10.1097/00005072-199901000-00002
M3 - Article
C2 - 10068309
AN - SCOPUS:0345683498
VL - 58
SP - 12
EP - 21
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
SN - 0022-3069
IS - 1
ER -