Neuronal Inclusions

Dennis W Dickson, W. L. Lin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neuronal inclusions are valuable histological features in establishing an accurate neuropathological diagnosis of neurodegenerative disorders, but they also have provided insight into the underlying molecular pathology of these disorders. This review provides an overview of the most common neuronal inclusions, both cytoplasmic and intranuclear, in the aging human brain and in a range of neurodegenerative disorders, focusing on their appearance with routine histological methods, as well as by immunohistochemistry and electron microscopy.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages441-455
Number of pages15
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Keywords

  • Aging
  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • FUS
  • Huntington's disease
  • Lewy body
  • Neurofibrillary tangle
  • P62/sequestosome
  • Parkinson's disease
  • Pick's disease
  • Tau
  • TDP-43
  • Ubiquitin
  • α-synuclein

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Dickson, D. W., & Lin, W. L. (2014). Neuronal Inclusions. In Encyclopedia of the Neurological Sciences (pp. 441-455). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00595-9