Neuronal Inclusions

D. W. Dickson; W. L. Lin

doi:10.1016/B978-0-12-385157-4.00595-9

Neuronal Inclusions

D. W. Dickson, W. L. Lin

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Neuronal inclusions are valuable histological features in establishing an accurate neuropathological diagnosis of neurodegenerative disorders, but they also have provided insight into the underlying molecular pathology of these disorders. This review provides an overview of the most common neuronal inclusions, both cytoplasmic and intranuclear, in the aging human brain and in a range of neurodegenerative disorders, focusing on their appearance with routine histological methods, as well as by immunohistochemistry and electron microscopy.

Original language	English (US)
Title of host publication	Encyclopedia of the Neurological Sciences
Publisher	Elsevier Inc.
Pages	441-455
Number of pages	15
ISBN (Electronic)	9780123851574
ISBN (Print)	9780123851581
DOIs	https://doi.org/10.1016/B978-0-12-385157-4.00595-9
State	Published - Jan 1 2014

Keywords

Aging
Alzheimer's disease
Amyotrophic lateral sclerosis
FUS
Frontotemporal dementia
Huntington's disease
Lewy body
Neurofibrillary tangle
P62/sequestosome
Parkinson's disease
Pick's disease
TDP-43
Tau
Ubiquitin
α-synuclein

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-385157-4.00595-9

Cite this

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abstract = "Neuronal inclusions are valuable histological features in establishing an accurate neuropathological diagnosis of neurodegenerative disorders, but they also have provided insight into the underlying molecular pathology of these disorders. This review provides an overview of the most common neuronal inclusions, both cytoplasmic and intranuclear, in the aging human brain and in a range of neurodegenerative disorders, focusing on their appearance with routine histological methods, as well as by immunohistochemistry and electron microscopy.",

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AU - Lin, W. L.

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AB - Neuronal inclusions are valuable histological features in establishing an accurate neuropathological diagnosis of neurodegenerative disorders, but they also have provided insight into the underlying molecular pathology of these disorders. This review provides an overview of the most common neuronal inclusions, both cytoplasmic and intranuclear, in the aging human brain and in a range of neurodegenerative disorders, focusing on their appearance with routine histological methods, as well as by immunohistochemistry and electron microscopy.

KW - Aging

KW - Alzheimer's disease

KW - Amyotrophic lateral sclerosis

KW - FUS

KW - Frontotemporal dementia

KW - Huntington's disease

KW - Lewy body

KW - Neurofibrillary tangle

KW - P62/sequestosome

KW - Parkinson's disease

KW - Pick's disease

KW - TDP-43

KW - Tau

KW - Ubiquitin

KW - α-synuclein

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SP - 441

EP - 455

BT - Encyclopedia of the Neurological Sciences

PB - Elsevier Inc.

ER -

Neuronal Inclusions

Abstract

Keywords

ASJC Scopus subject areas

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