Neuronal gene expression correlates of Parkinson's disease with dementia

Chelsea Stamper, Andrew Siegel, Winnie S. Liang, John V. Pearson, Dietrich A. Stephan, Holly Shill, Don Connor, John Nathaniel Caviness, Marwan Sabbagh, Thomas G. Beach, Charles Howard Adler, Travis Dunckley

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Dementia is a common disabling complication in patients with Parkinson's disease (PD). The underlying molecular causes of Parkinson's disease with dementia (PDD) are poorly understood. To identify candidate genes and molecular pathways involved in PDD, we have performed whole genome expression profiling of susceptible cortical neuronal populations. Results show significant differences in expression of 162 genes (P < 0.01) between PD patients who are cognitively normal (PD-CogNL) and controls. In contrast, there were 556 genes (P < 0.01) significantly altered in PDD compared to either healthy controls or to PD-CogNL cases. These results are consistent with increased cortical pathology in PDD relative to PD-CogNL and identify underlying molecular changes associated with the increased pathology of PDD. Lastly, we have identified expression differences in 69 genes in PD cortical neurons that occur before the onset of dementia and that are exacerbated upon the development of dementia, suggesting that they may be relevant presymptomatic contributors to the onset of dementia in PD. These results provide new insights into the cortical molecular changes associated with PDD and provide a highly useful reference database for researchers interested in PDD.

Original languageEnglish (US)
Pages (from-to)1588-1595
Number of pages8
JournalMovement Disorders
Volume23
Issue number11
DOIs
StatePublished - Aug 15 2008

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Parkinson Disease
Dementia
Gene Expression
Pathology
Genes
Research Personnel
Genome
Databases
Neurons

Keywords

  • Dementia
  • Gene expression
  • Laser capture microdissection
  • mRNA splicing
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Stamper, C., Siegel, A., Liang, W. S., Pearson, J. V., Stephan, D. A., Shill, H., ... Dunckley, T. (2008). Neuronal gene expression correlates of Parkinson's disease with dementia. Movement Disorders, 23(11), 1588-1595. https://doi.org/10.1002/mds.22184

Neuronal gene expression correlates of Parkinson's disease with dementia. / Stamper, Chelsea; Siegel, Andrew; Liang, Winnie S.; Pearson, John V.; Stephan, Dietrich A.; Shill, Holly; Connor, Don; Caviness, John Nathaniel; Sabbagh, Marwan; Beach, Thomas G.; Adler, Charles Howard; Dunckley, Travis.

In: Movement Disorders, Vol. 23, No. 11, 15.08.2008, p. 1588-1595.

Research output: Contribution to journalArticle

Stamper, C, Siegel, A, Liang, WS, Pearson, JV, Stephan, DA, Shill, H, Connor, D, Caviness, JN, Sabbagh, M, Beach, TG, Adler, CH & Dunckley, T 2008, 'Neuronal gene expression correlates of Parkinson's disease with dementia', Movement Disorders, vol. 23, no. 11, pp. 1588-1595. https://doi.org/10.1002/mds.22184
Stamper C, Siegel A, Liang WS, Pearson JV, Stephan DA, Shill H et al. Neuronal gene expression correlates of Parkinson's disease with dementia. Movement Disorders. 2008 Aug 15;23(11):1588-1595. https://doi.org/10.1002/mds.22184
Stamper, Chelsea ; Siegel, Andrew ; Liang, Winnie S. ; Pearson, John V. ; Stephan, Dietrich A. ; Shill, Holly ; Connor, Don ; Caviness, John Nathaniel ; Sabbagh, Marwan ; Beach, Thomas G. ; Adler, Charles Howard ; Dunckley, Travis. / Neuronal gene expression correlates of Parkinson's disease with dementia. In: Movement Disorders. 2008 ; Vol. 23, No. 11. pp. 1588-1595.
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