Neuronal gene expression correlates of Parkinson's disease with dementia

Chelsea Stamper, Andrew Siegel, Winnie S. Liang, John V. Pearson, Dietrich A. Stephan, Holly Shill, Don Connor, John N. Caviness, Marwan Sabbagh, Thomas G. Beach, Charles H. Adler, Travis Dunckley

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Dementia is a common disabling complication in patients with Parkinson's disease (PD). The underlying molecular causes of Parkinson's disease with dementia (PDD) are poorly understood. To identify candidate genes and molecular pathways involved in PDD, we have performed whole genome expression profiling of susceptible cortical neuronal populations. Results show significant differences in expression of 162 genes (P < 0.01) between PD patients who are cognitively normal (PD-CogNL) and controls. In contrast, there were 556 genes (P < 0.01) significantly altered in PDD compared to either healthy controls or to PD-CogNL cases. These results are consistent with increased cortical pathology in PDD relative to PD-CogNL and identify underlying molecular changes associated with the increased pathology of PDD. Lastly, we have identified expression differences in 69 genes in PD cortical neurons that occur before the onset of dementia and that are exacerbated upon the development of dementia, suggesting that they may be relevant presymptomatic contributors to the onset of dementia in PD. These results provide new insights into the cortical molecular changes associated with PDD and provide a highly useful reference database for researchers interested in PDD.

Original languageEnglish (US)
Pages (from-to)1588-1595
Number of pages8
JournalMovement Disorders
Volume23
Issue number11
DOIs
StatePublished - Aug 15 2008

Keywords

  • Dementia
  • Gene expression
  • Laser capture microdissection
  • Parkinson's disease
  • mRNA splicing

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Neuronal gene expression correlates of Parkinson's disease with dementia'. Together they form a unique fingerprint.

  • Cite this

    Stamper, C., Siegel, A., Liang, W. S., Pearson, J. V., Stephan, D. A., Shill, H., Connor, D., Caviness, J. N., Sabbagh, M., Beach, T. G., Adler, C. H., & Dunckley, T. (2008). Neuronal gene expression correlates of Parkinson's disease with dementia. Movement Disorders, 23(11), 1588-1595. https://doi.org/10.1002/mds.22184