Neuronal ganglionic acetylcholine receptor autoimmunity

Steven Vernino, Vanda A Lennon

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We have developed and validated an assay to detect serum antibodies specific for the ganglionic AChR. The assay uses ganglionic AChR solubilized from membranes of the human neuroblastoma cell line (IMR-32) as antigen. The ganglionic AChR is radiolabeled by complexing with 125I-epibatidine. Among patients with acquired dysautonomia, seropositivity is highly associated with the diagnosis of idiopathic or paraneoplastic autonomic neuropathy and can distinguish these disorders from other forms of autonomic dysfunction. Ganglionic AChR binding antibodies are detectable in 50% of patients with subacute autoimmune autonomic neuropathy (AAN). These patients often have a high antibody value (>0.2 nmol/L). Lower values (0.05-0.20 nmol/L) are found in ∼10% of patients with limited AAN.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume998
DOIs
StatePublished - 2003

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Keywords

  • Autonomic neuropathy
  • Gastrointestinal dysmotility
  • Orthostatic hypotension
  • Thymoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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