Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis

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Abstract

Objective: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. Methods: Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG. Results: Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004). Interpretation: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse.

Original languageEnglish (US)
Pages (from-to)566-569
Number of pages4
JournalAnnals of Neurology
Volume59
Issue number3
DOIs
StatePublished - Mar 2006

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Transverse Myelitis
Neuromyelitis Optica
Immunoglobulin G
Recurrence
Optic Neuritis
Myelitis
Magnetic Resonance Imaging
Prospective Studies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{67867d2a027948249eb94fdd9a1e64e0,
title = "Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis",
abstract = "Objective: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. Methods: Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG. Results: Eleven of 29 patients (37.9{\%}) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44{\%}) developed recurrent transverse myelitis and 1 of 9 (11{\%}) developed optic neuritis (p = 0.004). Interpretation: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40{\%} of patients who are seropositive for NMO-IgG are at high risk for relapse.",
author = "Weinshenker, {Brian G} and Wingerchuk, {Dean Marko} and Sandra Vukusic and Linda Linbo and Pittock, {Sean J} and Lucchinetti, {Claudia F} and Lennon, {Vanda A}",
year = "2006",
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doi = "10.1002/ana.20770",
language = "English (US)",
volume = "59",
pages = "566--569",
journal = "Annals of Neurology",
issn = "0364-5134",
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TY - JOUR

T1 - Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis

AU - Weinshenker, Brian G

AU - Wingerchuk, Dean Marko

AU - Vukusic, Sandra

AU - Linbo, Linda

AU - Pittock, Sean J

AU - Lucchinetti, Claudia F

AU - Lennon, Vanda A

PY - 2006/3

Y1 - 2006/3

N2 - Objective: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. Methods: Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG. Results: Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004). Interpretation: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse.

AB - Objective: We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis (LETM) predicts relapse of myelitis or development of optic neuritis. Methods: Prospective study of patients with initial LETM who were tested for the presence of NMO-IgG. Results: Eleven of 29 patients (37.9%) were seropositive after a first attack of LETM spanning three or more vertebral segments on magnetic resonance imaging. Of 23 patients followed up for 1 year, none of 14 who were seronegative experienced a relapse or developed optic neuritis. Of 9 seropositive patients, 5 developed a second event: 4 of 9 (44%) developed recurrent transverse myelitis and 1 of 9 (11%) developed optic neuritis (p = 0.004). Interpretation: LETM represents an inaugural or limited form of NMO in a high proportion of patients. The 40% of patients who are seropositive for NMO-IgG are at high risk for relapse.

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