Neuromyelitis Optica

Marcelo Matiello, Brian G Weinshenker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neuromyelitis optica (NMO) is a severe idiopathic autoimmune disease of the central nervous system (CNS). Most NMO patients are seropositive for the highly specific autoantibody (NMO-IgG), which targets aquaporin-4. In vitro and in vivo studies have shown that NMO-IgG is not just a diagnostic biomarker for NMO; it is an essential component of NMO pathophysiology. In this chapter, we discuss the current status of the diagnosis and treatment of NMO and highlight that the understanding of NMO-IgG-driven mechanisms may lead to specific therapies in the near future.

Original languageEnglish (US)
Title of host publicationMultiple Sclerosis and CNS Inflammatory Disorders
PublisherWiley Blackwell
Pages153-162
Number of pages10
ISBN (Print)9781118298633, 9780470673881
DOIs
StatePublished - Aug 25 2014

Keywords

  • Aquaporin-4
  • Devic's disease
  • LETM
  • Neuromyelitis optica
  • NMO-IgG

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Matiello, M., & Weinshenker, B. G. (2014). Neuromyelitis Optica. In Multiple Sclerosis and CNS Inflammatory Disorders (pp. 153-162). Wiley Blackwell. https://doi.org/10.1002/9781118298633.ch15