Neuromuscular Disorders and Sleep in Critically Ill Patients

Muna Irfan, Bernardo Selim, Alejandro A. Rabinstein, Erik K. St Louis

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Sleep-disordered breathing (SDB) is a frequent presenting manifestation of neuromuscular disorders and can lead to significant morbidity and mortality. If not recognized and addressed early in the clinical course, SDB can lead to clinical deterioration with respiratory failure. The pathophysiologic basis of SDB in neuromuscular disorders, clinical features encountered in specific neuromuscular diseases, and diagnostic and management strategies for SDB in neuromuscular patients in the critical care setting are reviewed. Noninvasive positive pressure ventilation has been a crucial advance in critical care management, improving sleep quality and often preventing or delaying mechanical ventilation and improving survival in neuromuscular patients.

Original languageEnglish (US)
Pages (from-to)533-550
Number of pages18
JournalCritical Care Clinics
Issue number3
StatePublished - Jul 1 2015


  • Critical care
  • Intensive care unit
  • Management
  • Neuromuscular disorders
  • Sleep
  • Sleep disorders

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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