Neurological prognostication of outcome in patients in coma after cardiac arrest

Andrea O. Rossetti, Alejandro Rabinstein, Mauro Oddo

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

Management of coma after cardiac arrest has improved during the past decade, allowing an increasing proportion of patients to survive, thus prognostication has become an integral part of post-resuscitation care. Neurologists are increasingly confronted with raised expectations of next of kin and the necessity to provide early predictions of long-term prognosis. During the past decade, as technology and clinical evidence have evolved, post-cardiac arrest prognostication has moved towards a multimodal paradigm combining clinical examination with additional methods, consisting of electrophysiology, blood biomarkers, and brain imaging, to optimise prognostic accuracy. Prognostication should never be based on a single indicator, although some variables have very low false positive rates for poor outcome, multimodal assessment provides resassurance about the reliability of a prognostic estimate by offering concordant evidence.

Original languageEnglish (US)
Pages (from-to)597-609
Number of pages13
JournalThe Lancet Neurology
Volume15
Issue number6
DOIs
StatePublished - May 1 2016

Fingerprint

Coma
Heart Arrest
Electrophysiology
Neuroimaging
Resuscitation
Biomarkers
Outcome Assessment (Health Care)
Technology
Neurologists

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Neurological prognostication of outcome in patients in coma after cardiac arrest. / Rossetti, Andrea O.; Rabinstein, Alejandro; Oddo, Mauro.

In: The Lancet Neurology, Vol. 15, No. 6, 01.05.2016, p. 597-609.

Research output: Contribution to journalReview article

@article{72d05b86820c4df7a800298ce59baea1,
title = "Neurological prognostication of outcome in patients in coma after cardiac arrest",
abstract = "Management of coma after cardiac arrest has improved during the past decade, allowing an increasing proportion of patients to survive, thus prognostication has become an integral part of post-resuscitation care. Neurologists are increasingly confronted with raised expectations of next of kin and the necessity to provide early predictions of long-term prognosis. During the past decade, as technology and clinical evidence have evolved, post-cardiac arrest prognostication has moved towards a multimodal paradigm combining clinical examination with additional methods, consisting of electrophysiology, blood biomarkers, and brain imaging, to optimise prognostic accuracy. Prognostication should never be based on a single indicator, although some variables have very low false positive rates for poor outcome, multimodal assessment provides resassurance about the reliability of a prognostic estimate by offering concordant evidence.",
author = "Rossetti, {Andrea O.} and Alejandro Rabinstein and Mauro Oddo",
year = "2016",
month = "5",
day = "1",
doi = "10.1016/S1474-4422(16)00015-6",
language = "English (US)",
volume = "15",
pages = "597--609",
journal = "The Lancet Neurology",
issn = "1474-4422",
publisher = "Lancet Publishing Group",
number = "6",

}

TY - JOUR

T1 - Neurological prognostication of outcome in patients in coma after cardiac arrest

AU - Rossetti, Andrea O.

AU - Rabinstein, Alejandro

AU - Oddo, Mauro

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Management of coma after cardiac arrest has improved during the past decade, allowing an increasing proportion of patients to survive, thus prognostication has become an integral part of post-resuscitation care. Neurologists are increasingly confronted with raised expectations of next of kin and the necessity to provide early predictions of long-term prognosis. During the past decade, as technology and clinical evidence have evolved, post-cardiac arrest prognostication has moved towards a multimodal paradigm combining clinical examination with additional methods, consisting of electrophysiology, blood biomarkers, and brain imaging, to optimise prognostic accuracy. Prognostication should never be based on a single indicator, although some variables have very low false positive rates for poor outcome, multimodal assessment provides resassurance about the reliability of a prognostic estimate by offering concordant evidence.

AB - Management of coma after cardiac arrest has improved during the past decade, allowing an increasing proportion of patients to survive, thus prognostication has become an integral part of post-resuscitation care. Neurologists are increasingly confronted with raised expectations of next of kin and the necessity to provide early predictions of long-term prognosis. During the past decade, as technology and clinical evidence have evolved, post-cardiac arrest prognostication has moved towards a multimodal paradigm combining clinical examination with additional methods, consisting of electrophysiology, blood biomarkers, and brain imaging, to optimise prognostic accuracy. Prognostication should never be based on a single indicator, although some variables have very low false positive rates for poor outcome, multimodal assessment provides resassurance about the reliability of a prognostic estimate by offering concordant evidence.

UR - http://www.scopus.com/inward/record.url?scp=84962846991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962846991&partnerID=8YFLogxK

U2 - 10.1016/S1474-4422(16)00015-6

DO - 10.1016/S1474-4422(16)00015-6

M3 - Review article

C2 - 27017468

AN - SCOPUS:84962846991

VL - 15

SP - 597

EP - 609

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 6

ER -