Neurological injury in adults treated with extracorporeal membrane oxygenation

Farrah J. Mateen, Rajanandini Muralidharan, Russell T. Shinohara, Joseph E. Parisi, Gregory J. Schears, Eelco F.M. Wijdicks

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

Background: Extracorporeal membrane oxygenation (ECMO) may be urgently used as a last resort form of life support when all other treatment options for potentially reversible cardiopulmonary injury have failed. Objective: To examine the range and frequency of neurological injury in ECMO-treated adults. Design: Retrospective clinicopathological cohort study. Setting: Mayo Clinic, Rochester, Minnesota. Patients: A prospectively collected registry of all patients 15 years or older treated with ECMO for 12 or more hours from January 2002 to April 2010. Intervention: Patients were analyzed for potential risk factors for neurological events and death using logistic regression and Cox proportional hazards models. Main Outcome Measures: Neurological diagnosis and/or death. Results: A total of 87 adults were treated (35 female [40%]; median age, 54 years [interquartile range, 31]; mean duration of ECMO, 91 hours [interquartile range, 100]; overall survival ≲γτ∀7 days after ECMO, 52%). Neurological events occurred in 42 patients who received ECMO (50%; 95% confidence interval [CI], 39%-61%). Diagnoses included subarachnoid hemorrhage, ischemic watershed infarctions, hypoxic-ischemic encephalopathy, unexplained coma, and brain death. Death in patients who received ECMO who did not require antecedent cardiopulmonary resuscitation was associated with increased age (odds ratio,1.24 per decade; 95% CI, 1.03- 1.50; P=.02) and lower minimum arterial oxygen pressure (odds ratio, 0.79; 95% CI, 0.68-0.92; P=.03). Although stroke was rarely diagnosed clinically, 9 of 10 brains studied at autopsy demonstrated hypoxic-ischemic and hemorrhagic lesions of vascular origin. Conclusion: Severe neurological sequelae occur frequently in adult ECMO-treated patients with otherwise reversible cardiopulmonary injury (conservative estimate, 50%) and include a range of potentially fatal neurological diagnoses that may be due to the precipitating event and/or ECMO treatment.

Original languageEnglish (US)
Pages (from-to)1543-1549
Number of pages7
JournalArchives of neurology
Volume68
Issue number12
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Mateen, F. J., Muralidharan, R., Shinohara, R. T., Parisi, J. E., Schears, G. J., & Wijdicks, E. F. M. (2011). Neurological injury in adults treated with extracorporeal membrane oxygenation. Archives of neurology, 68(12), 1543-1549. https://doi.org/10.1001/archneurol.2011.209