Neurological complications of peripheral and cutaneous T-cell lymphomas

David K. Kaufman, Thomas Matthew Habermann, Paul J. Kurtin, Brian Patrick O'Neill

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To determine the frequency and pattern of neurological complications of T- cell lymphoma (TCL), we retrospectively reviewed the medical records of 316 patients with TCL diagnosed between January 1984 and May 1991. Disease entities not included in this study were lymphoblastic lymphoma, primary central nervous system lymphoma, CD30-positive anaplastic large cell lymphoma, and lymphomas secondary to human immunodeficiency virus or human T- cell lymphotropic virus type 1. Cases were classified as having direct complications (parenchymal, leptomeningeal, epidural, or peripheral) or indirect complications (paraneoplastic, disease related, or treatment related). Preexisting neurological conditions were excluded. The overall rate of neurological complications was 7.9%. The frequency of neurological complications in peripheral TCL and cutaneous TCL was 17% and 3%, respectively, with at least half of the neurological complications in both conditions due to direct involvement of the nervous system. Direct neurological complications of TCL were primarily due to leptomeningeal and parenchymal involvement. There were no cases of epidural spinal cord disease.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalAnnals of Neurology
Volume36
Issue number4
DOIs
StatePublished - Oct 1994

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Peripheral T-Cell Lymphoma
Cutaneous T-Cell Lymphoma
T-Cell Lymphoma
Lymphoma
Anaplastic Large-Cell Lymphoma
Preexisting Condition Coverage
Human T-lymphotropic virus 1
Spinal Cord Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Nervous System
Medical Records
Central Nervous System
HIV
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurological complications of peripheral and cutaneous T-cell lymphomas. / Kaufman, David K.; Habermann, Thomas Matthew; Kurtin, Paul J.; O'Neill, Brian Patrick.

In: Annals of Neurology, Vol. 36, No. 4, 10.1994, p. 625-629.

Research output: Contribution to journalArticle

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